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ID:55573113
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页数:2页
时间:2020-05-18
《慢性心力衰竭并肾功能不全患者外周血同型半胱氨酸和中性粒细胞明胶酶相关脂质运载蛋白的相关性研究.pdf》由会员上传分享,免费在线阅读,更多相关内容在行业资料-天天文库。
1、现代医院2015年7月第l5卷第7期专业技术篇ModernHospitalJul2015Vol15No7慢性心力衰竭并肾功能不全患者外周血同型半胱氨酸和中性粒细胞明胶酶相关脂质运载蛋白的相关性研究李剑平STUDYONTHELEVELSOFHOMOCYSTElNlNANDNEUTROPHILGELATINASEASSOCI—ATEDLlPOCALINlNPATlENTSWITHCHRONICHEARTFAILURECOMBINEDINSUFFI—CIENTRENALFUNCTIONL/Jianpin
2、g【摘要】目的探讨慢性心力衰竭并肾功能不全患者外周血同型半胱氨酸(homocystein,Hey)和中性粒细胞明胶酶相关脂质运载蛋白(neutrophilgelatinaseassociatedlipocalin,NGAL)的表达及两者的相关性研究。方法选取2013年6月~2014年6月入住南方医科大学北涪医院心血管内科的慢性心力衰竭患者58例,其中合并肾功能不全患者28例,未合并肾功能不全患者30例。心脏超声检测左室射血分数(1eftventricularejectionfraction,LVE
3、F),检测外周血BNP、血肌酐、Hcy、以及NGAL的表达。结果与慢性心力衰竭患者相比,外周血Hcy浓度和NGAL水平在慢性心力衰竭合并肾功能不全患者中升高(P<0.05);相关性分析显示所有入选患者外周血中Hcy浓度与NGAL水平呈正相关;Hcy浓度与NGAL水平分别与BNP浓度、血肌酐水平呈正相关(P<0.05),与LVEF呈负相关(P<0.05)。结论外周血Hcy和NGAL水平可反映慢性心力衰竭并肾功能不全患者的发生发展。【关键词】慢性心力衰竭肾功能不全中性粒细胞明胶酶相关脂质运载蛋白同型半
4、胱氨酸【Abstract】0bjectiveToinvestigatethelevelsofhomocysteininandneutrophilgelatinaseassociatedlipocalinanditsrela—tionshipinpatientswithchronicheaafailurecombinedinsuficientrenalfunction.Methotis58patientswithchronicheartfailurewereenrolledinfromJune201
5、3toJune2014inBeijiaohospitalaffiliatedSouthernmedicaluniversity.Thereinto,accordingtopa—tient’scondition.28patientswerechronicheartfailureconcurrenceinsumcientrenalfunetion.30patientswerechronicheartfailure.Leftventficularejectionfractionweredetermine
6、dbycardiacultrasound,thelevelsofserumBNP,Hcy,NGALandcreatinewerede—termined.ResultsComparedwithchronicheartfailurepatients.thelevelsofHcyandNGALwereincreasedinpatientswithchronicheaafailureconcurrenceinsumcientrenalfunction(P<0.05).Correlationanalysis
7、showedthatthelevelsofHcyispositivelycore-latedwiththelevelsofNGAL(P<0.05);thelevelsofHcyandNGALwerepositivelycorelatedwithBNPandcreatine(P<0.05),butnegativelycorelatedwithLVEF(P<0.05),respectively.ConclusionCirculatinglevelsofHcyandNGALcanreflectthede
8、-velopmentofchronicheartfailureconcurrenceinsuficientrenalfunction.【Keywords】chronicheartfailure;insuficientrenalfunction;neutrophilgelatinaseassociatedlipocalin;homocysteinin【Authorsaddress】Beijiaohospital,Southernmedicaluniversity,Shunde,Fos
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