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时间:2020-05-09
《白细胞介素-6、白细胞介素-10、肿瘤坏死因子-α与冠心病关系的初步研究.pdf》由会员上传分享,免费在线阅读,更多相关内容在行业资料-天天文库。
1、2Tiar~jinMedJ,November2014,Vo1.42No.11白细胞介素一6、白细胞介素一1O、肿瘤坏死因子一仪与冠心病关系的初步研究董军姜华陈树涛【摘要】目的研究炎症细胞因子白细胞介素(IL)一6、肿瘤坏死因子(TNF)一Ot、IL一10等与冠心病(CHD)发病的关系。方法选取冠心病患者628例,同期经冠脉造影证实冠脉无狭窄的非冠心病患者540例为对照组,记录患者的资料,包括年龄、体质指数(BMI)、血糖(Glu)、总胆固醇(TC)、三酰甘油(TG)、高密度脂蛋白胆固醇(HDL—C)、低密度脂蛋白胆固醇(LDL—C)等
2、指标,同时用酶联免疫吸附试验法检测血清IL一6、IL一10、TNF—d等炎症因子水平。结果CHD组BMI、LDL—C、TG水平均高于对照组,而HDL—C水平低于对照组(均P3、014.11.017ThePreliminar、,StudyoftheRelationshipbetweenlL-6,IL-10,TNF-~andCoronaryArteryDiseaseDONGJunI,JIANGHua2,CHENShutaoJDepartmentofCICUofTianjinChestHospital,Tianjin300222.China;2DepartmentCardiology,TianfinCheseHospitalCorrespondingAuthorE—maihshutaochen2099@126.c4、om[Abstract】ObjectiveTostudytherelationshipbetweencoronarya~erydisease(CHD)andinterleukin一6(IL一6),TNF一0【andIL一10.MethodsPatientswithCHDwereincludedinCHDgroup(n=628)andpatientswithoutCHDcon—firmedbycoronaryangiographywereselectedincontrolgroup(n=540).Therecordeddatainclu5、dedage,bodymassindex(BMI)andserumlevelsofglucose(GLU),totalcholesterolC),triglyceride(TG),highdensitylipoprotein—cholesterol(HDL—C)andlowdensitylipoprotein—cholesterol(LDL-C).MeanwhileserumlevelsofIL一6,TNF一,IL一10weredeterminedbyELISA.ResultsSerumlevelsofBMI,LDL—C,TGwere6、higherinCHDgroupthanthoseincontrolgroup(P<0.01).TheserumlevelofHDL—CwassignificantlylowerinCHDgroupthanthatincontrolgroup(P<0.01).SerumlevelsofIL一6(P‘0.05)andTNF一0【(P<0.01)werehigherinCHDgroupthanthoseincontrolgroup.TheserumlevelofIL一10wassignificant—lylowerinCHDgroupth7、anthatincontrolgroup(P<0.O1).ConclusionIL一6andTNF—dareinvolvedinthedevelop—mentofCHD.IL一10caninhibitinflammationandprotectvesselintegrity.【Keywords】coronarydisease;interleukin-6;interleukin一10;tumornecrosisfactor—alpha随着人们生活水平的提高,寿命的延长,冠心病1月一2014年3月期间住院患者中经冠脉造影明确为冠心(CHD8、)已经成为人类健康的一大威胁。随着对病者628例(不含急性心肌梗死患者),为CHD组;选取同期经冠脉造影证实冠脉无狭窄的非冠心病患者540例为对照CHD研究的深入,人们逐渐认识到炎症反应及炎症组。所有研究对象均排除糖尿病
3、014.11.017ThePreliminar、,StudyoftheRelationshipbetweenlL-6,IL-10,TNF-~andCoronaryArteryDiseaseDONGJunI,JIANGHua2,CHENShutaoJDepartmentofCICUofTianjinChestHospital,Tianjin300222.China;2DepartmentCardiology,TianfinCheseHospitalCorrespondingAuthorE—maihshutaochen2099@126.c
4、om[Abstract】ObjectiveTostudytherelationshipbetweencoronarya~erydisease(CHD)andinterleukin一6(IL一6),TNF一0【andIL一10.MethodsPatientswithCHDwereincludedinCHDgroup(n=628)andpatientswithoutCHDcon—firmedbycoronaryangiographywereselectedincontrolgroup(n=540).Therecordeddatainclu
5、dedage,bodymassindex(BMI)andserumlevelsofglucose(GLU),totalcholesterolC),triglyceride(TG),highdensitylipoprotein—cholesterol(HDL—C)andlowdensitylipoprotein—cholesterol(LDL-C).MeanwhileserumlevelsofIL一6,TNF一,IL一10weredeterminedbyELISA.ResultsSerumlevelsofBMI,LDL—C,TGwere
6、higherinCHDgroupthanthoseincontrolgroup(P<0.01).TheserumlevelofHDL—CwassignificantlylowerinCHDgroupthanthatincontrolgroup(P<0.01).SerumlevelsofIL一6(P‘0.05)andTNF一0【(P<0.01)werehigherinCHDgroupthanthoseincontrolgroup.TheserumlevelofIL一10wassignificant—lylowerinCHDgroupth
7、anthatincontrolgroup(P<0.O1).ConclusionIL一6andTNF—dareinvolvedinthedevelop—mentofCHD.IL一10caninhibitinflammationandprotectvesselintegrity.【Keywords】coronarydisease;interleukin-6;interleukin一10;tumornecrosisfactor—alpha随着人们生活水平的提高,寿命的延长,冠心病1月一2014年3月期间住院患者中经冠脉造影明确为冠心(CHD
8、)已经成为人类健康的一大威胁。随着对病者628例(不含急性心肌梗死患者),为CHD组;选取同期经冠脉造影证实冠脉无狭窄的非冠心病患者540例为对照CHD研究的深入,人们逐渐认识到炎症反应及炎症组。所有研究对象均排除糖尿病
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