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《癌症患者输乏白细胞红细胞前后TNF-α和IL-10的变化及其临床意义.pdf》由会员上传分享,免费在线阅读,更多相关内容在行业资料-天天文库。
1、·16·实用临床医学2014年第15卷第l1期PracticalClinicalMedicine。2014。Vol15,No11癌症患者输乏白细胞红细胞前后TNF一0【i~flIL一10的变化及其临床意义蒋红飞.陆卫(1.南通市中医院检验科,江苏南通226001;2.海门市人民医院输血科,江苏南通226002)摘要:目的探讨癌症患者输血前后TNF—Ot和IL一10的变化及其意义。方法选取23例癌症并贫血患者,用EUSA法分别测定患者输血(输乏白细胞红细胞)前1d和输血后第1天和第5天的血清TNF—和IL—lO的含量。结果输血
2、前1d、输血后第l天和输血后第5天血清TNF—含量分别为(1.42+0.48)、(2.55i-O.84)和(5.11±1.22)·II,.1O含量分别为(686~1.09)、(9.93+1.48)和(9.83_+1.30)g·L-l。TNF-d含量输血前ld、输血后第1天和输。血后第5天比较差异有统计学意义(均P3、F一0l;IL一10中图分类号:R730.5文献标志码:A文章编号:1009—8194(2014)11-0016—02ChangesinTNF-txandIL-10beforeandafterLeukocyte-DepletedBloodTransfusionsinCancerPatientsandTheirClinicalSignificanceJIANGHong-~i,LUWei(1.DepartmentofLaboratoryMedicine,NantongHospitalofTraditionalChineseMed4、icine,Nantong226001,China;2.DepartmentofBloodTransfusion,HaimenPeople’sHospital,Nantong226002,China)ABSTRACT:ObjectiveToinvestigatethechangesinTNF一仅andIL-IObeforeandafterleukocyte—depletedbloodtransfusionsincancerpatientsandtheirclinicalsignificance.MethodsTheserum5、concentrationsofTNF..OtandIL—.10weremeasuredbyELISAonthedaybeforeleukocyte—-depletedbloodtransfusionsandonthefirstandfifthdaysafterbloodtransfusionsin16cancerpatientswithanemia.ResultsTheconcentrationsofTNF—OtandIL-10were,respectively,(1.42~0.48)lxg·Land(6.86~1.09)6、~g·IJ_onthedaybeforebloodtransfusions,(2.55~0.84)1~g·Land(9.93~1.48)~g·Lonthefirstdayafterbloodtransfusions,and(5.11~1.22)~g·Land(9.83~1.30)~g·Lonthefifthdayafterbloodtransfusions.ThedifferencesinTNF—OLconcentrationsweresignificantamongthethreedays0.O1).Thedifferen7、cesinIL一10concentrationsweresignificantbetweenthedaybeforebloodtransfusionsandthefirstdayafterbloodtransfusionsfP<0.01).ConclusionTheimmunosuppressionispresentincancerpatientstransfusedwithleukocyte—depletedblood.Theenhancementofriskassessmentcanprovideappropriatea8、ssistanceforclinicalbloodtransfusions.1EYWoRDS:cancerpatients;leukoeyte—depletedbloodtransfusions;TNF一仪;IL一10肿瘤为慢性消耗性疾病。易导致贫血的发生。养、暂停放化疗等治疗病因之外,常
3、F一0l;IL一10中图分类号:R730.5文献标志码:A文章编号:1009—8194(2014)11-0016—02ChangesinTNF-txandIL-10beforeandafterLeukocyte-DepletedBloodTransfusionsinCancerPatientsandTheirClinicalSignificanceJIANGHong-~i,LUWei(1.DepartmentofLaboratoryMedicine,NantongHospitalofTraditionalChineseMed
4、icine,Nantong226001,China;2.DepartmentofBloodTransfusion,HaimenPeople’sHospital,Nantong226002,China)ABSTRACT:ObjectiveToinvestigatethechangesinTNF一仅andIL-IObeforeandafterleukocyte—depletedbloodtransfusionsincancerpatientsandtheirclinicalsignificance.MethodsTheserum
5、concentrationsofTNF..OtandIL—.10weremeasuredbyELISAonthedaybeforeleukocyte—-depletedbloodtransfusionsandonthefirstandfifthdaysafterbloodtransfusionsin16cancerpatientswithanemia.ResultsTheconcentrationsofTNF—OtandIL-10were,respectively,(1.42~0.48)lxg·Land(6.86~1.09)
6、~g·IJ_onthedaybeforebloodtransfusions,(2.55~0.84)1~g·Land(9.93~1.48)~g·Lonthefirstdayafterbloodtransfusions,and(5.11~1.22)~g·Land(9.83~1.30)~g·Lonthefifthdayafterbloodtransfusions.ThedifferencesinTNF—OLconcentrationsweresignificantamongthethreedays0.O1).Thedifferen
7、cesinIL一10concentrationsweresignificantbetweenthedaybeforebloodtransfusionsandthefirstdayafterbloodtransfusionsfP<0.01).ConclusionTheimmunosuppressionispresentincancerpatientstransfusedwithleukocyte—depletedblood.Theenhancementofriskassessmentcanprovideappropriatea
8、ssistanceforclinicalbloodtransfusions.1EYWoRDS:cancerpatients;leukoeyte—depletedbloodtransfusions;TNF一仪;IL一10肿瘤为慢性消耗性疾病。易导致贫血的发生。养、暂停放化疗等治疗病因之外,常
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