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时间:2020-05-07
《慢性肾衰竭患者血清血管细胞黏附分子-1与血管性假性血友病因子水平变化及临床意义-论文.pdf》由会员上传分享,免费在线阅读,更多相关内容在应用文档-天天文库。
1、·1648·检验医学与临床2014年6月第11卷第12期IabMedClin,June2014,Vo1.11,No.12·论著·慢性肾衰竭患者血清血管细胞黏附分子一1与血管性假性血友病因子水平变化及临床意义邱波,梁卫东,刘善军(济宁医学院附属医院肾内科,山东济宁272000)【摘要】目的探讨慢性肾衰竭患者血清血管细胞黏附分子一1(vCAM一1)与血管性假性血友病因子(vWF)的变化及临床意义,以及血液透析对其水平的影响。方法应用酶联免疫吸附试验(ELASA)测定30例慢性肾衰竭未透析患者(CRF组)、30例血液透析患者(HD组)、30例健康自愿者(健康对照组)血清VCAM
2、一1与vwF的水平,并比较透析前后的变化。结果VCAM一1水平在HD组、cRF组及健康对照组分别为(7638.4-4-372.2)ng/mL、(6723.5±136.4)ng/mI、(2901.3±253.2)ng/mL,HD组、CRF组明显高于健康对照组,差异均有统计学意义(P<0.01,P<0.01)。vwF水平在HD组、CRF组以及健康对照组分别为(241.7±13.5)、(165.6±7.9)、(90.5±10.8),HD组、cRF组明显高于健康对照组,差异有统计学意义(P<0.01,P<0.05)。血清VCAM一1透析后(7863.4±186.3)ng/mL较透
3、析前(7638.4±372.2)ng/mL明显升高,差异有统计学意义(P4、vWFinpatientswithchronicrenalfailureandtheirclinicalsignificanceQIUB0,LIANG—dong,L儿,Shahjun(DepartmentofNephrology,AffiliatedHospitalofJiningMedicalCollege,Jining272000。C^ina)[Abstract]ObjectiveToinvestigatethechangeofplasmaVCAM一1andvWFinpatientswithchronicrenalfailureandtheirclinica1sign5、ificance,andtheinfluenceofhemodialysis.MethodsThe1evelsofplasmaVCAM一1andvWFweremeasuredinCRFpatientswithouthemodialysis(CRFgroup,n一30)。hemodialysispatients(HDgroup,一30)andcontrolgroup(n一30)bythemethodofenzymelinkedimmunosorbentassay(ELISA).ResultsThelevelsofplasmaVCAM一1inHDgroupwerehigher6、thanCRFgroup,boththetwogroupsweresignificantlyhigherthanthecontrolgroup,thevalueofthreegroupsrespectivelywere(7638.4±372.2)ng/mI,(6723.5±136.4)ng/mI,(2901.3-4-253.2)ng/mI(P7、8)(P
4、vWFinpatientswithchronicrenalfailureandtheirclinicalsignificanceQIUB0,LIANG—dong,L儿,Shahjun(DepartmentofNephrology,AffiliatedHospitalofJiningMedicalCollege,Jining272000。C^ina)[Abstract]ObjectiveToinvestigatethechangeofplasmaVCAM一1andvWFinpatientswithchronicrenalfailureandtheirclinica1sign
5、ificance,andtheinfluenceofhemodialysis.MethodsThe1evelsofplasmaVCAM一1andvWFweremeasuredinCRFpatientswithouthemodialysis(CRFgroup,n一30)。hemodialysispatients(HDgroup,一30)andcontrolgroup(n一30)bythemethodofenzymelinkedimmunosorbentassay(ELISA).ResultsThelevelsofplasmaVCAM一1inHDgroupwerehigher
6、thanCRFgroup,boththetwogroupsweresignificantlyhigherthanthecontrolgroup,thevalueofthreegroupsrespectivelywere(7638.4±372.2)ng/mI,(6723.5±136.4)ng/mI,(2901.3-4-253.2)ng/mI(P7、8)(P
7、8)(P
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