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《2012年扬州市麻风疫苗效价与基础免疫成功率监测分析.pdf》由会员上传分享,免费在线阅读,更多相关内容在行业资料-天天文库。
1、江苏预防医学2013年11月第24卷第6期JiangsuJPrevMed,November,2013,Vo1.24,No.6论N-O2012年扬州市麻风疫苗效价与基础免疫成功率监测分析朱道建,杨冬梅,罗德威江苏省扬州市疾病预防控制中心,扬州225002摘要:目的了解扬州市麻疹风疹联合减毒活疫苗(简称麻风疫苗)的效价和免疫成功率,考核疫苗管理和冷链运转状况。方法采集6O名8月龄儿童麻风疫苗免疫前、后1个月双份血清标本,分别进行麻疹、风疹IgG抗体测定。选择市、县疾病预防控制中心和乡接种点各2支麻风疫苗,采用微
2、量细胞板培养法检测,进行麻风疫苗效价测定。结果免后麻疹抗体阳性59人,阳性率98.33,免疫成功58人,免疫成功率96.67,GMT1:1285.13;风疹抗体阳性35人,阳性率58.33,免疫成功35人,免疫成功率58.33,GMT1:19.67;市、县、乡三个点的麻风疫苗效价均在10TCID5。/o.1mL以上,均为合格疫苗。结论扬州市疫苗管理和冷链系统运转状况良好,能保证疫苗的质量。麻风疫苗所包含的麻疹成分免疫原性好,风疹成分免疫原性较差。须进行后续的加强免疫是必要的,还应适时开展大中学生麻风类疫苗追
3、加免疫。关键词:麻风疫苗;效价;免疫成功率中图分类号:R186文献标识码:A文章编号:1006—9070(2013)06—0031—02Analysisonsurveillance0ftiterandbasicimmunizationsuccessrate0fmeasles-rubellavaccineinYangzhou。2012ZHUDao—jian,YANGDong—mei,LU0De—weiYangzhouMunicipalCenterforDiseaseControlandPrevention,Y
4、angzhou225002,ChinaAbstract:ObjectiveToinvestigatethetiterandimmunizationsuccessrateofattenuatedmeas1es-rubeUavaccine(MRvaccine);tOassessthevaccineadministrationandcoldchaintransportationstatus.MethodsDoubleserumsamples(1monthbeforeandaftervacci—nationofMR
5、)of608-year-oldchildrenwerecollectedfordetectingIgGlevelsagainstmeaslesandrubella.2vialsofvaccinesweretakenfromYangzhoumunicipalCDC。GaoyoucountyCIX;andloca1vaccinationservicecenterrespectivelytoevaluatethetiterofMRvaccinebymicrocellplateculturing.ResultsAf
6、tervaccination,59participantswerepositiveformeaslesantibody,positiveratewas98.33.58participantsweresuccessfullyimmunized,resultingasuccessfulrateof96.67,GMTwas1:l285.13.35participantswerepositiveforrubellaantibody,positiveratewas58.33,35participantsweresuc
7、cessfullyimmunized,resultingasuccessfulrateof58.33,GMTwas1:19.67.MRvaccinesfromYangzhoumunicipalCDC,GaoyoucountyCDCandlocalvaccinationservicecenterwereallqualified,allwithtitersabove10TCID50/0.1mLConclusionVaccineadministrationandcoldchaintransportationrun
8、wel1inYangzhou,qualityofvaccinescouldbeguaranteed.MRvaccineshavegoodimmunogenicityformeaslesbutnotforrubella.En—hancedimmunizationisnecessary,especiallyforcollegeandhighschoolstudents.Keywords:Measles—Rubella
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