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时间:2020-05-02
《全麻手术对患者血小板CD62p和CD63表达的影响.pdf》由会员上传分享,免费在线阅读,更多相关内容在行业资料-天天文库。
1、实用检验医师杂志2013年9月第5卷第3期ChineseJournalofClinicalPatholo~ist,Seotember2013,Vo1.5,No.3·179·全麻手术对患者血小板CD62p和CD63表达的影响王升庞雁康红灿李新刚作者单位:455000安阳市.河南安阳地区医院血液实验室【摘要】目的观察全麻手术后血小板CD62p和CD63的变化,探讨全麻手术对血小板活化的影响。方法利用流式细胞术检测1l2例全麻手术患者麻醉诱导前、手术结束后、术后3d血小板CD62p和CD63表达水平,并进行统计学分析。
2、结果手术结束后及术后3d的CD62p表达水平分别与麻醉诱导前比较,差异均无统计学意义(P均>0.05);手术结束后的CD63表达水平与麻醉诱导前比较,差异有统计学意义(P<0.05),但术后3d与麻醉诱导前比较,差异无统计学意义(P均>0.05)。结论全麻手术后血小板的活化有明显的增强。增加患者术后发生血栓的风险。【关键词】全麻手术;流式细胞术;CD62p;CD63doi:10.3969/j.issn.1674-7151.2013.03.012Theinfluenceofsurgeryundergeneralan
3、esthesiatoCD62pandCD63ofplateletWANGSheng,PANGYan,KANGHong-can,eta1.DepartmentofHematologicalLaboratory,theAnyangRegionalHospital,Anyang455000,China【Abstract】ObjectiveTomonitorthelevelsofCD62pandCD63ofplateletinpatientsacceptedsurgeryundergeneralanesthesiaand
4、toexploretheinfluenceofsurgeryundergeneralanesthesiatoactivatedstateofplatelet.MethodsFlowcytometrywasusedtomeasurethelevelsofCD62pandCD63ofplatelet(be-forethegeneralanesthesia,immediatelyafterthesurgery,threedaysafterthesurgery)in112patientsre—eeivedsurgeryu
5、ndergeneralanesthesia,andtheresultswereanalyzedstatistically.ResultsThelevelofCD62pinimmediatelyafterthesurgeryandthreedaysafterthesurgerywereallhigherthaninbeforethegen—eralanesthesia,butthediferenceswereallhadnostatisticalsignificance(Pall>0.05).ThelevelofC
6、D63inimmediatelyafterthesurgerywashigherthaninbeforethegeneralanesthesia,andthediferencehadstatisti—calsignificance(P<0.05),buttherewasnostatisticalsignificanceinthedifferenceofCD63levelbetweenthreedaysafterthesurgeryandbeforethegeneralanesthesia(P>O.05).Conc
7、lusionThereisvisiblerein—forcementactivatedofplateletaftersurgeryundergeneralanesthesia,whichincreasetheriskofthrombus.【Keywords】Operationundergeneralanesthesia;Flowcytometry;CD62p;CD63在临床工作中,全麻手术患者经常发生深静脉我院112例全麻手术患者,男性52例,女性60例,血栓(deepvenousthrobosis,DVT),对
8、患者造成致命年龄20—78岁。其中外科肿瘤患者46例(胃癌19的伤害。血小板是血栓组成的重要成分,血小板活化例、结肠癌27例)、骨科骨折患者及关节置换患者与血栓的形成存在着密切的关系_】]。P一选择素38例、妇科疾病患者28例(乳腺癌11例、子宫肌瘤(CD62p)和溶酶体蛋白(CD63)均为识别活化血小板7例、子宫颈癌1O例)。手术时间90—180min。的分子标志物,C
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