中性粒细胞明胶酶相关性脂质运载蛋白与子痫前期的相关性-论文.pdf

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1、●医学院学报2013年第35卷第645ldoi：10-．3969／j．issn．10043101．2013．06．015中性粒细胞明胶酶相关性脂质运载蛋白与子痫前期的相关性沈承承“。，董素芹’。(潍坊医学院妇产科学教研室，山东潍坊261053；潍坊医学院附属潍坊市人民医院产科)CorrelationbetweenNeutrophilGelatinase-associatedlipocalin(NGAL)andPreeclampsia(PE)。。SHENChen—chenDONGSu—ngg，qi’(Department矿ObstetricsandGynecology

2、，WeifangMedicalCollege，Wetfang261053，China；。DepartmentofObstetrics，WetfangPeople§HospitalAffiliatedt0WetfangMedicalCollege)—[ABSTRACT]ObjectiveTodetectserumneutrophilgelatinaseassociatedlipocalinfNeutrophilgelatinase．as．sociatedlipocalin，NGAL)inpreeclampsia，andtoexplorerelationshipsbet

3、weenpreeclampsiaandrenaldamagetoguideclinicaldianosisandtreatment．g．MethodsUsingenzyme1inkedimmunosorhentassaydetectionofseverepreeclampsia(casegroup：30patientswithearlyonsetandlateonsetroucases)normallate—renantwomencontrolrougp，30，pg(gp：gestationalage≤34weekscontrolgroupof30cases，ges

4、tationalage>34weeks30patients)serumNGALlevels；auto．mariebiochemistranalzerbloodbiochemicalindicesand24hoursroteinuria。yyp．ResultsIntheearlyonsetgroupandlateonsetgroup，serumNGALexpressionwassignificantlyhigherthanthecontrolgroup，SerumNGALlevelsinpre—eelampsiawererelatedwithserumuricacid

5、andtotalurinaryprotein．ConclusionSerumlevelsofNGALex[)ressionin—creaseinpreeclampsia，anditsuggeststhatNGALmaybeassociatedwithrenaldsfunctionandarelikeltoarticiatey，yppthroughdifferentpathwaysinthepathophysiologyofpreeclampsia．Itcanbeusedasassessmentofpreeclampsiainpa．tientswithend—oran

6、damaeandtheseveritofabiochemicalmarkerwhichuse(1tomonitorthefunctionalstatusoftheggy．parentorganinvolved，SOthattimelyterminationofpregnancyandmaternalcanachievethebestoutcome．，[KEYWORDS]Preeclampsia；Pregnantwoman：SerumNGAL[作者简介]沈承承(1987年～)，女(汉族)，山东省临沂市人，在滨硕士研究生。主要研究方向：围产医学。-ahoo[通讯作者]董

7、素芹，Email：wfdongsq@y．COB452ActaAcadMedWeifangVo1．35No．62013子痫前期(preeclampsia，PE)是孕期严重的并发为对照组。各组孕妇均系单胎，早发型组和晚发型组症J，孕妇的风险主要是终末器官的损伤，终止妊娠孕周与同期对照组的年龄、BMI(体重指数)比较均无是目前唯一可以治愈PE的方法，分娩时机应同时考统计学意义(P>0．05)。B超排除胎儿畸形，且已排虑孕妇及胎儿因素，评估PE患者终末器官的损伤程除有原发性高血压病、糖尿病、心脏病、肾病、肿瘤、血度有利于选择分娩时机，达到最佳的母婴预后。延长液系统疾病、