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1、TheprofessionalEnglishofpharmaceuticalengineeringWangXinliangEastChinauniversityofscienceandtechnology09.04.2012capsulesemulsionsyruptabletsuspensionointmentcreamelixir胶囊乳剂糖浆片剂混悬剂软膏霜剂酒剂Theparenteralrouteofadministrationisimportantintreatingmedicalemergencies（
2、inwhichasubjectiscomatoseorcannotswallow）,andinprovidingvarioustypesofmaintenancetherapyforhospitalizedpatients.Ifpatientself-administrationcannotbeachieved,thesalesofthedrugconstituteonlyasmallfractionofwhatthemarketwouldbeotherwise.Thereasonsforthispreferen
3、ceareasfollows.Tabletsandcapsulesrepresentunitdosageformsinwhichoneusualdoseofthedrughasbeenaccuratelyplaced.Bycomparison,liquidoraldosageforms,suchassyrups,suspensions,emulsions,solutions,andelixirs,areusuallydesignedtocontainonedoseofmedicationin5to30ml.Pro
4、pertiesTheobjectiveofthedesignandmanufactureofthecompressedtabletistodeliverorallythecorrectamountofdrugintheproperformatoroverthepropertimeandinthedesiredlocation,andtohaveitschemicalintegrityprotectedtothatpoint.Asidefromthephysicalandchemicalpropertiesofth
5、emedicinalagent(s)tobeformulatedintoatablet,theactualphysicaldesign,manufacturingprocess,andcompletechemicalmakeupofthetabletcanhaveaprofoundeffectontheefficacyofthedrug(s)beingadministered.Atablet(1)shouldbeanelegantproducthavingitsownidentitywhilebeingfreeo
6、fdefectssuchaschips,cracks,discoloration,contamination,andthelike;(2)shouldhavethestrengthtowithstandtherigorsofmechanicalshocksencounteredinitsproduction,packaging,shipping,anddispensing;and(3)shouldhavethechemicalandphysicalstabilitytomaintainitsphysicalatt
7、ributeovertime.Pharmaceuticalscientistsnowunderstandthatvariousphysicalpropertiesoftabletscanundergochangeunderenvironmentalorstressconditions,andthatphysicalstability,throughitseffectonbioavailabilityinparticular,canbeofmoresignificanceandconcerninsometablet
8、systemsthanchemicalstability.9Thankyou此课件下载可自行编辑修改，此课件供参考！部分内容来源于网络，如有侵权请与我联系删除！
