乙型肝炎抗病毒治疗停药后复发与血清hbvdna水平的相关性分析_司慧远.doc

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1、乙型肝炎抗病毒治疗停药后复发与血清HBVDNA水平的相关性分析司慧远，李晓娟，王纯巍，周平(解放军空军总医院，北京100142)［摘耍］目的探讨乙型肝炎(HB)抗病瞬治疗停约后复发与血HBVDNA水平的相关性°方法选取180例接受阿徳福韦酯治疗的HB患者，检测患者治疗前及治疗4周后血清HBVDNA水平。结果HBeAg(+)时，治疗前HBVDNA水平A107copyies/mL复发率是56%,10“〜10copies/mL复发率是36%,＜10r.copies/mL复发率是10%,HBVDNA水平＞107copies/mL停药复发率报高，＜10fico

2、pies/mL报低。治疗4周后，HBVDNA水平＜103copies/mL复发率是18%,较基线下降幅度＞3lgcopics/mL者复发率是20%,较基线下降幅度2Igcopies/mL者复发率是21%,较基线下降幅度1lgcopies/mL者复发率是37%,HBVDNA水平＜10^copies/mL复发率最低较基线下降幅度IIgcopies/mL者复发率最高。HBeAg(-)时.治疗前IIBVDNA水平〉10?copies/mL复发率是27%,106〜10?copies/mL复发率是11%,<106copies/mL复发率是7%,HBVDNA水平

3、〉10?copies/mL停药复发率瑕高。治疗4周后，HBVDNA水平＜l(hcopies/mL复发率是6%,较基线下降幅度＞3Igcopies/tnL者复发率是10%,较基线下降幅度2lgcopics/mL者复发率是11%,较基线卜降幅度1Igcopies/mL者复发率是63%,HBVDNA水平＜10copies/'mL复发率最低。较基线F降幅度1lg-copies/mL者复发率故高。结论HB患者抗病毒治疗停药后复发和患者治疗前的血清HBVDNA水平、治疗早期HBVDNA水平及血清HBVDNA水平降幅存在相关性。［关键词］乙型肝炎；复发；HBVDN

4、A：抗病毒doi：10.3969/j・issn.100X—S849.2014.03.008［中图分类号］R512.62［文献标识码］A［文章编号］1008—8849(2014)03一0248一03CorrelationanalysisbetweenrecurrenceafterantiviraltreatmentofhepatitisBstoppedandserumHBVDNAlevelSiHuiyuan,LiXiaojuan.WangChunwci,ZhouPing(AirForceGeneralHospitalofPLA,Beijing10014

5、2.China)Abstract：ObjectiveItistoapproachthecorrelationbetweenrecurrenceafterantiviraltreatmentofhepatitisBstoppedandserumHBVDNAlevel.Methods180hepatitisBpatientstreatedwithAdefovirDipivoxilwereselectedtthesemmHBVDNAlevelsofthemweredetectedbeforetreatmentand4weeksaftertreatment.

6、ResultsAsHBeAg(+〉，beforetreatmentstherecurrenceratewas56%forHBVDNAlevel>10?copies/mL,36%CorHBVDNAlevelsfrom1()6to10?copies/mL,and10%forHBVDNAlevels<106copies/mL,therecurrencerateof!IBVDNAlevels>10?copies/mLwashighest,<106copies/mLwaslowest.After4weekstreatmentstherecurrencerate

7、was18%forHBVDNAlevel<10scopiesimL,20%fordown>3Igcopies/mLcomparedwithbaseline,21%fordrop2Igcopies/mL.37%fordropIIgcopies/mL,therecurrencerateofHBVDNAlevel<103copies/mLwaslowest,dropIlgcopies/mLwashighest.AsHBeAg(—),beforetreatment,therecurrenceratewas27%forHBVDNAlevel>10?copie

8、s/mL,11%forHBVDNAlevelfrom106to107copies/rnLrand7%for