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1、哮喘患者血清巨噬细胞炎症蛋白一la表达和其临床意义［摘要］目的观察哮喘患者巨噬细胞炎症蛋白-la(MIP-1a)在血清中的表达，探讨其与哮喘严重度的关系。方法选取诸暨市中心医院2012年3〜10月确诊为哮喘的患者80例，根据病程不同分为A组哮喘发作期患者(40例)，B组哮喘缓解期患者(40例)，另选取同期C组40例健康者作为对照。测定各组研究对象MIP-la浓度、外周血嗜酸性粒细胞计数(EOS)和第1秒用力呼气容积(FEV1)占预计值百分比。结果①A组血清MIP-la表达水平为(51・2±6・4)ng/L,明显高于B组的(23.5±3.7)ng/L(t=23.698,P=0.0
2、00)及C组(15.1±2.8)ng/L(t=32.683,P二0.000)；与C组比较，B组MIP-1a水平明显升高(t二11.450,P=0.000)。②在外周血EOS计数的比较中，A组为(0.51±0.34)X109/L,B组为(0.26±0.19)X109/L,均显著高于C组的(0.13±0.08)X109/L(tac二11.658,Pac=0.000；tbc=3.988,Pbc=0.000)；与B组比较，A组明显升髙(t二4.059,P二0.000)o③FEV1占预计值百分比的比较中，A组为(53.7±17.6)%,B组为(68.2±16.3)%均显著低于。组［(88
3、.4±12.5)%］(tac二10.166,Pac=0.000；tbc=6.220,Pbc二0.000）；与B组比较，A组明显降低(t=3.823,P=0.000)o④A组患者血清MIP-la浓度与外周血EOS计数之间呈正相关(r=0.422,P0.05)o结论哮喘发作期时血清MIP-1a表达水平明显增高，与外周血EOS计数和FEV1占预计值百分比之间存在明显的相关关系，监测血清MIP-la的水平对哮喘具有一定的诊断价值。［关键词］哮喘；巨噬细胞炎症蛋白-la；嗜酸性粒细胞［中图分类号］R562.25［文献标识码］A［文章编号］1673-7210(2013)11(c)-0066
4、-04Expressionandclinicalsignificaneeofserummacrophageinflaminatoryprotein~lalphaofasthmaWANGQianglZHUXinmin21.DepartmentofEmergency,theCentralHospitalofZhujiCity,ZhejiangProvince,Zhuji311800,China；2.DepartmentofRespiratoryMedicine，People，sHospitalofZhujiCity，ZhejiangProvince,Zhuji311800,Chin
5、a［Abstract］ObjectiveToobservetheexpressionandclinicalsignificanceofserummacrophageinflammatoryprotein-1alpha(MIP-1a)ofasthma・Methods80patientswithasthmaintheCentralHospitalofZhujiCityfromMarchtoOctoberin2012wereselectedanddividedintotwogroupsbydifferentprocessofthedisease・40onsetasthmaticpat
6、ientsweredevidedintogroupA,theother40paracmasticasthmaticpatientsweredevidedintogroupB,another40hea1thindividualswerecollectedasgroupC(controlgroup)・ThelevelsofMIP-1a,thenumberofeosinophilicgranulocyte(EOS)andthepercentageofFEV1inpredictionamongthreegroupsweremeasured・ResuIts①ThelevelofMIPTa
7、ingroupA[(51.2+6.4)ng/L]washigherthaningroupB[(23・5±3・7)ng/L]andgroupC[(15.1±2.8)ng/L](tab二23.698,Pab二0.000；tac=32.683,Pac=0.000)・ThelevelofMIPTciingroupBwashigherthanthatingroupC(t二11.450,P=0.000).②ThenumberofEOSingroupA[(0.51+0.34)X109/L]andingro
