观察芪苈强心胶囊早期防治糖尿病伴射血分数保留心力衰竭的疗效.pdf

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1、中国疗养医学2017年第26卷第1期ChinJConvalescentMed，Jan.2017，Vol.26，No.1·77·观察芪苈强心胶囊早期防治糖尿病伴射血分数保留心力衰竭的疗效周琳李嘉俊任继刚【摘要】目的观察芪苈强心胶囊干预糖尿病伴早期射血分数保留心力衰竭(HFpEF)的临床疗效。方法选择成都市第六人民医院2014-02—2016-02收治的112例糖尿病伴早期HFpEF的患者，将其随机分为两组，其中对照组56例给予常规西药抗心衰治疗，观察组56例再加用芪苈强心胶囊。分别于治疗前、治疗12周时分析和比较两组的总有效率及早期二尖瓣最大血流速度(EV)

2、、晚期二尖瓣最大血流速度(AV)、血管紧张素Ⅱ(AngⅡ)及醛固酮、明尼苏达评分(MLHFQ)及Lee氏评分等指标。结果治疗后两组比较，观察组总有效率高于对照组(91.1%比71.4%)，且心衰早期(A、B期)有效率更高(95.1%比70.0%)(P＜0.05)；观察组患者的EV及LVEF较对照组有改善，AV、醛固酮、Lee氏评分及明尼苏达评分均较对照组降低，差异有统计学意义(P＜0.05)。结论芪苈强心胶囊可改善糖尿病伴早期HFpEF患者的临床症状及其左室舒张功能。【关键词】芪苈强心胶囊；射血分数保留的心衰；血管紧张素；醛固酮【Abstract】Obje

3、ctiveToobservetheclinicaleffectofQiliqiangxincapsulesintheinterventionofearlyheartfailurewithpreservedejectionfraction(HFpEF)accompaniedwithdiabetes.MethodsAtotalof112suffererswithHFpEFaccompaniedwithdiabetesadmittedtoChengduNo.6HospitalfromFebruary2014toFebruary2016wererandomlydi

4、videdintotwogroups.56sufferersinthecontrolgroupweretreatedwithroutinewesternmedicineforanti-heartfailuretreatment，while56sufferersintheobservationgroupweretreatedwithadditionalQiliqiangxincapsules.Thetotaleffectiverate，EV，AV，AngⅡ，aldosteronelevel，MLHFQscoreandLeescaleinbothgroupsp

5、riortreatmentandafter12weeksoftreatmentwereanalyzedandcompared.ResultsAftertreatment，thetotaleffectiverateoftheobservationgroupwashigherthanthatofthecontrolgroupwith91.1%and71.4%，especiallywithahighereffectiverateforearlyheartfailure(stageA，B)with95.1%and70.0%(P＜0.05).Comparedwith

6、thecontrolgroup，EVandLVEFintheobservationgroupgotimproved，andAV，aldosteronelevel，Leescale，andMLHFQscoreintheobservationgroupreduced，withdifferencesofstatisticalsignificance(P＜0.05).ConclusionQiliqiangxincapsulescaneffectivelyimprovethesymptomsandleftventriculardiastolicfunctionofe

7、arlyheartfailurewithpreservedejectionfraction(HFpEF)accompaniedwithdiabetes.【Keywords】Qiliqiangxincapsule；Heartfailurewithpreservedejectionfraction；Angiotensin；Aldosterone射血分数保留的心力衰竭(HFpEF)主要指的病时是否具有相应的疗效和安全性尚未可知。本是左心室收缩功能正常或略微下降，心室主动松研究旨在探讨中药配方芪苈强心胶囊辅助治疗弛及心肌顺应性减少或处于顿抑状态，导致心室糖尿病患者

8、合并HFpEF的临床疗效，选择左室舒充盈不够及充盈压增高引起心力衰