资源描述：
《接触热痛觉,感觉定量分析》由会员上传分享，免费在线阅读，更多相关内容在行业资料-天天文库。
1、NeuroscienceLetters316(2001)79–82www.elsevier.com/locate/neuletContactheatevokedpotentialsasavalidmeanstostudynociceptivepathwaysinhumansubjectsAndrewC.N.Chen*,DavidM.Niddam,LarsArendt-NielsenHumanBrainMappingandCorticalImagingLaboratory,TheInternationalDoctoralSchoolinBiomedica
2、lSciencesandEngineering,CentreforSensory–MotorInteraction,AalborgUniversity,FredrikBajerVej7,D-3,Aalborg9220,DenmarkReceived9August2001;receivedinrevisedform10October2001;accepted10October2001AbstractContactheatevokedpotentials(CHEPs)havebeendifficulttoelicitduetoslowtemperaturer
3、isetimes.Arecentlydevelopedheat-foiltechnologywasusedtoelicitpainandCHEPs.Twogroupsofsubjectswereseparatelystimulatedattheleftarmwithcontactheatviaonefast-acting(708C/s)heat-foilthermode.AsetofCHEPswasrecorded,eachatthreesubjectiveintensities:warm;slight;andmoderatepain.InCHEPs,
4、the3Dtopographyexhibitedfourcomponents:T3–T4/N450;Cz/N550;Cz/P750;andPz/P1000.AvertextopographymapwasobservedinthelateCz/N550–Cz/P750andparietaltopographyinthevery-latePz/P1000components.Consistentstatisticalvaluesinthepeaklatenciesandamplitudeswerenotedbetweenconsecutiveinvesti
5、gations.ThecorrelationbetweenthepainintensityratingsandthemajorCz/P750amplitudeswashighlysignificantineachstudy.OurvaliditytestssuggestedCHEPstobeusefulforresearchandclinicalapplicationsinstudyinghumanpainactivationrelatedtothermalandnociceptivepathways.q2001ElsevierScienceIrelan
6、dLtd.Allrightsreserved.Keywords:Contactheatevokedpotentials;Painperception;Late/very-latecomponents;Consistency;Thin-fibreafferentAlthoughheatpainexaminedbylaserevokedpotentialsagedevokedpotentialstocontactheathaverarelybeen(LEPs)hasbeenstudiedfor25years[2,6],thecoherentstudied.H
7、ere,wereportanewlydevelopedheat-foilwithbeamanditssmallstimulationarea(,5mmdiameter)arapidrisingtimeat708C/stoelicitcontactheatevokedmaynotconstituteanaturalactivationasincontactheat.potentials(CHEPs).Theaimsofthisstudywereto:(a),Inaddition,laserstimuliaretoobrieftosimulatereall
8、ifeexaminethe3Dspatio-temporaldynamictopography
