多索茶碱治疗哮喘及慢性阻塞性肺病７０例临床观察

《多索茶碱治疗哮喘及慢性阻塞性肺病７０例临床观察》由会员上传分享，免费在线阅读，更多相关内容在工程资料-天天文库。

1、多索茶碱治疗哮喘及慢性阻塞性肺病70例临床观察【摘要】目的：观察多索茶碱治疗喘息性疾病的效果。方法：多索茶碱与氨茶碱进行对比观察，治疗组共70例，用多索茶碱300mg力［1入5%的葡•萄糖注射液250ml中静滴,每天一次，用药7天：对照组用氨茶碱注射液，每次25Omg加入5%葡萄糖注射液250m1中静滴，用药7天，观察两组患者临床疗效和两组患者肺功能参数。结果：临床疗效治疗组85.6%、对照组71.7%,FEV1治疗组总有效率为88.5%、对照组为75.0%,FEV1FVC治疗组总有效率为87.1%、对照组为73.3%,而不良反应发生率明显低于对照组。治疗组与

2、对照组之间有显著性差异（PV0.05）结论：多索茶碱治疗支气管哮喘和慢性阻塞性肺病疗效显著。【关键词】多索茶碱;氨茶碱;支气管哮喘；阻塞性肺病Thec1•1n•1ca10bservaIion0fdoxofy11ineinject•10nfor70caseofbronchia1asthmaandC0PDYANGHongyu(FengTia]QH0spita1Affi1iatedt0shenYangMedica1Co1lege,medicament0ussection110024)Abstractot>jective：Toobservetheeffectofdoxo

3、fy1lineinjeclionforpal•1entswiIhbronchia1asthmaandC0PD.Meth0ds••Comparisonbetweendoxofy11ineandanfy11ine.710caseoftheremedialgr0upweretreatedforaweekwithintraven0us•1nfusionof30Omgofdoxofyl1ine•1n•Ject•1onwhichwasaddedto2;50mlofg11UCO£;e*90nceaday.Thecontr•o1groupweretreatedforaweekw

4、ithintravenousinfus■10n0f250mgofaminophy11ineinjectionwh•1chwasaddedto250ml0fg11licose,onceaday•Thec1inica1curativeeffeetoftw0gr0uP0fpatientswascomparedintheP0sttreatment.Thelung:functionparameters0ftwogr0upsarecomparedafterp0sttreatment.Resu1t：IntheculraIiveeffect9thetota1effectiver

5、alewas85.6%•1nLhed0Xify11inegroupandthatwas71.7%•1ncontro1group.1nFEV1(foreedexpirat0ryVo1umeonesecond),thetota1effect•Veratewas88.5%intheremedialgroupandthatwas75.0%incontrolgroup.IntheratioofFEV1toFVC(forcevitalcapaci1iy)9thetotaleffectiveratewas87.1%■1ntheremedia1groupandthatwas73

6、.3%•1nc0ntro1group.TheiricidentrateofadVerseeffeetwas1owerthanthatofthec0ntro1grouPobvi0us1y•Thereweres1gn•1f•1cantd■1fferencesbetweenthedoxofy11■1negr0uPandthecontro1group(P<0■05)c0nc1us•10n:Theff€Jctofdoxofyl1ine•1n•Ject•10nf0rpatientswithbronch•1a1asthmaandc0pD♦1s0bv♦10uSo[KeyW0rd

7、]dC►xofy11ine；amin0phy11•1ne■9br0nch♦1a1asthma；C0PD(chr0nic0bstruct■10nPu1m0narydisease)茶碱类药物广泛应用于哮喘及慢性阻塞性肺病已有近rr年的历史，以往临床研究表明，氨茶碱能减轻慢性阻塞性肺病患者（C0PD）的呼吸困难，改善呼吸肌功能，刺激低氧状态下的呼吸驱动，但山于其心悸、恶心、呕吐等不良反应，使其临床应用受到限制。近几年,多索茶碱（doxofyl1ine）的问世犬人改善了茶碱类药物的用药局面，多索茶碱具有较强的平喘作川，同时安全性明显高于茶碱及氨茶碱，是替代茶碱类药物的新

8、一代甲基瞟吟衍生物°本文