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1、FromRECISTtoPERCIST:EvolvingConsiderationsforPETResponseCriteriainSolidTumorsRichardL.Wahl1,2,HeatherJacene1,YvetteKasamon2,andMartinA.Lodge11DivisionofNuclearMedicine,DepartmentofRadiology,JohnsHopkinsUniversitySchoolofMedicine,Baltimore,Maryland;and2DepartmentofOncology,Jo
2、hnsHopkinsUniversitySchoolofMedicine,Baltimore,MarylandThepurposeofthisarticleistoreviewthestatusandlimitations3-cm-diameterregionofinterestintheliver,usingaconsistentofanatomictumorresponsemetricsincludingtheWorldHealthPETprotocol,usingafixedsmallregionofinterestabout1cm3Org
3、anization(WHO)criteria,theResponseEvaluationCriteriainvolume(1.2-cmdiameter)inthemostactiveregionofmetaboli-inSolidTumors(RECIST),andRECIST1.1.Thisarticlealsore-callyactivetumorstominimizestatisticalvariability,assessingviewsqualitativeandquantitativeapproachestometabolictu-
4、tumorsize,treatingSUVleanmeasurementsinthe1(upto5op-morresponseassessmentwith18F-FDGPETandproposestional)mostmetabolicallyactivetumorfocusasacontinuousadraftframeworkforPETResponseCriteriainSolidTumorsvariable,requiringa30%declineinSUVfor‘‘response,’’andde-(PERCIST),version1
5、.0.Methods:PubMedsearches,includingferringtoRECIST1.1incasesthatdonothave18F-FDGavidityorsearchesforthetermsRECIST,positron,WHO,FDG,cancer(in-aretechnicallyunsuitable.Criteriatodefineprogressionoftu-cludingspecifictypes),treatmentresponse,regionofinterest,mor-absentnewlesionsa
6、reuncertainbutareproposed.Con-andderivativereferences,wereperformed.Abstractsandarti-clusion:AnatomicimagingaloneusingstandardWHO,clesjudgedmostrelevanttothegoalsofthisreportwereRECIST,andRECIST1.1criteriahavelimitations,particularlyinreviewedwithemphasisonlimitationsandstre
7、ngthsoftheana-assessingtheactivityofnewercancertherapiesthatstabilizetomicandPETapproachestotreatmentresponseassessment.disease,whereas18F-FDGPETappearsparticularlyvaluableinOnthebasisofthesedataandtheauthors’experience,draftcri-suchcases.TheproposedPERCIST1.0criteriashoulds
8、erveteriawereformulatedforPETtumorresponsetotreatment.asastartingpointforus
