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ID:40812551
大小:741.27 KB
页数:16页
时间:2019-08-08
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1、REVIEWSAntiplatelettherapiesforthetreatmentofcardiovasculardiseaseAlanD.MichelsonAbstract
2、Antiplatelettherapyhasbeensuccessfulinreducingmortalityandmorbidityinacutemyocardialinfarction.Recentadvancesinunderstandingthemolecularbasisoftheroleofplateletsincardiovascularthrombosishave
3、enabledthedevelopmentofnewagentswiththepotentialtofurtherreducemortalityandmorbidity.Thisarticlereviewstheroleofplateletsinhaemostasisandcardiovascularthrombosis,anddiscussesthebenefitsandlimitationsofcurrentandinvestigationalantiplateletagentsinthetreatmentofcardiovasculardisease
4、.Themostcommoncauseofdeathinthedevelopedworldpotentantiplateleteffectandlesspatienthyporespon-Acutemyocardialinfarctionisacutemyocardialinfarction,whichiscausedbycoronarysiveness;targetingnewepitopestotrytoimproveoralPopularlyknownasaheartattack,thisisthedeathofarterythrombosis.Pl
5、ateletshaveacentralroleincardio-integrinαIIbβ3antagonists;andthedevelopmentofhearttissuefromlackofvascularthrombosis.Theyadheretothesubendothelialagentsdirectedagainstnewplateletsurfacetargetssuchoxygen,whichisusuallymatrixafterendothelialdamageduetoarupturedasproteinase-activated
6、receptor1(PAR1),plateletglyco-causedbyaclot(thrombosis)atheroscleroticplaque,thenaggregatewitheachotherproteinVI(GPVI),integrinα2β1,5-hydroxytryptamineinanarterythatsuppliesbloodtotheheart.toformaprothromboticsurfacethatpromotesclotfor-receptor2A(5HT2A),andprostaglandinE2receptorE
7、P3mationandsubsequentlyvascularocclusion.Asaresult,subtype(EP)withthegoalofbetterseparatingreduced3Thrombosistherapiestargetingkeypathwaysofplateletactivationthromboticeventsfromincreasedbleedingevents.Thedevelopmentofablood—includingthromboxaneAsynthesis,ADP-mediatedThisarticlepr
8、ovidesanoverviewoftheactionsandclotinthecirculatorysystem.2signallingandintegrinαIIbβ3(alsoknowasGPIIb–IIIa)rolesofplatelets,highlightingthecentralimportanceofDependingonthelocationoftheclot,theresultantlossofsignalling—haveestablishedaroleinthetreatmentofplateletsincardiovascular
9、disease.Approvedantiplateletcircu
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