Structural and material approaches for bone tissue

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1、Diss.ETHNo.21210Powderbasedthree-dimensionalprintingofcalciumphosphatestructuresforscaffoldengineeringAdissertationsubmittedtotheETHZURICHforthedegreeofDoctorofSciencespresentedbyAndréButscherDipl.Masch.-Ing.ETHBorn21stAugust,1974CitizenofGermanyacceptedontherecomme

2、ndationofProf.Dr.RalphMüller,examinerProf.Dr.MarcBohner,co-examiner2013bmeinerFamiliedTableofContentsiTableofContentsTableofContentsiAcknowledgementsiiiSummaryviiZusammenfassungxi1.Introduction11.1Thesismotivationandmedicalrelevance31.2Specificaims41.3Outlineoftheth

3、esis52.Background92.1Introductioninpowderbasedthree-dimensionalprinting112.2Reviewofadditivefabricationmethodsforscaffoldengineering143.Optimizationof3DPforscaffoldengineering453.1Powderparticleoptimization473.2Printingtechniqueoptimization854.Scaffolddesign1134.1In

4、troduction1154.2Newdepowdering-friendlydesign1185.Synthesis149Appendix159CurriculumVitae160Patent162iiAcknowledgementsiiiAcknowledgementsThisthesiswouldnothavebeenpossiblewithoutthesupportofmanytowhomIexpressmysinceregratitude.Firstly,IamprofoundlythankfultomyFriend

5、,LordandSaviorforYourloveandcountlessprovidences,evensavingmylifeduringmytraveltotheGRIBOIcongressinMilano.IamgratefulfortheendowmentofcreativityandthejoyinthesearchoftinyinsightsinYourawesomecreation.ThankYoufortheinspiredideasanddivineguidancethatalsopropelledmeto

6、finishthisthesis.Andforplacingmeclosetolovingandencouragingpeopleinmylife,Iameternallygrateful.MayallthehonorandpraisesbeYours.MysincereanddeepgratitudegototheRMSFoundation,namelyRobertMathysandBeatGasser.Thanksforyourtrust.Youhiredmebeinga“greenengineer”duringmytim

7、einSamoaservingasavolunteerteacher.Thereafter,youprovidedthebasisandthevitalresourcesforthisgreatopportunityofadoctoralthesisatETHZürichwhileworkingpart-timeattheRMSFoundation.Thishasbeenaninvaluableexperience.IwouldliketoexpressmydeepsenseofgratitudetomyPhDadvisors

8、,Prof.Dr.RalphMüllerandProf.Dr.MarcBohner.Thankyou,Ralph,forgivingmetheextraordinaryopportunitytogetalittleinsightintheoverwhelmingfieldof