1-HYDROXYETHYLIDENE-1,1-DIPHOSPHONIC ACID-羟基乙叉二膦酸

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1、1-HYDROXYETHYLIDENE-1,1-DIPHOSPHONICACIDNewspecificationspreparedat63rdJECFA(2004)andpublishedinFNP52Add12(2004).Levelsofresiduethatareexpectedtoremainonfoodsdonotrdposeasafetyconcern(63JECFA,2004).SYNONYMSHEDP,ethane-1-hydroxy-1,1-diphosphonicacid,EHDP,editronicacidDEFINITION1-Hydro

2、xyethylidene-1,1-diphosphonicacid(HEDP)ismanufacturedcommerciallybythereactionofphosphorousacidwithoneormoreacetylatingagents;specificallyaceticanhydride,acetylchlorideand/oraceticacid.Thefinalproductistypicallya60%solutionofHEDPinwater.Chemicalname1-hydroxyethylidene-1,1-diphosphoni

3、cacidC.A.S.number2809-21-4ChemicalformulaCH3C(OH)[PO(OH)2]2StructuralformulaHOOHOHHOPPCOOHOH3CEmpiricalformulaC2H8O7P2Formulaweight205.02AssayTotalactiveacid58–62%DESCRIPTIONClearpaleyellowliquid,freeofsuspendedmatterFUNCTIONALUSESSequestrant(foruseinantimicrobialwashingsolutions)CHA

4、RACTERISTICSIDENTIFICATIONSolubility(Vol.4)Misciblewithwater,phosphoricacidandethyleneglycol;solubleinmostorganicsolventspH(Vol.4)Notmorethan2.0(1%soln)Specificgravity(Vol.4)1.430-1.471at20ºFreezingpoint-25ºPURITYChlorideNotmorethan40mg/kgSeedescriptionunderTESTSPhosphorousacidNotmor

5、ethan4.0%SeedescriptionunderTESTSAceticacidNotmorethan1.0%SeedescriptionunderTESTSIron(Vol.4)Notmorethan10mg/kgDetermineusinganatomicabsorptiontechniqueappropriatetothespecifiedlevelArsenic((Vol.4)Notmorethan5mg/kgLead(Vol.4)Notmorethan5mg/kgDetermineusinganatomicabsorptiontechniquea

6、ppropriatetothespecifiedlevel.TheselectionofthesamplesizeandmethodofsamplepreparationmaybebasedontheprinciplesofthemethoddescribedinVolume4,“Instrumentalmethods”TESTSPURITYTESTSChlorideDeterminebypotentiometrictitrationbyplacing25gofthesample,accuratelyweighed,intoatitrationvesseland

7、addingsufficientwatertocovertheelectrodes.Add3mlofconcentratednitricacid.Titratewith0.005mol/lsilvernitratetofirstinflectionpointandrecordthetitreinml(A).Calculatethechloridecontent(mg/kg)from:Chloride(mg/kg)=[AxMx3.55x10000]/WwhereM=concentrationofsilvernitratesolution(mol/l)W=weigh

8、tofsampletak