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1、Biomaterials33(2012)7945e7951ContentslistsavailableatSciVerseScienceDirectBiomaterialsjournalhomepage:www.elsevier.com/locate/biomaterialsTheeffectoflightlycrosslinkedpoly(carboxybetaine)hydrogelcoatingontheperformanceofsensorsinwholebloodaaaaaabWeiYang,TaoBai,Loui
2、saR.Carr,AndrewJ.Keefe,JiajieXu,HongXue,ColleenA.Irvin,cda,*ShengfuChen,JosephWang,ShaoyiJiangaDepartmentofChemicalEngineering,UniversityofWashington,Box351750,Seattle,WA98195,USAbDepartmentofBioengineering,UniversityofWashington,Seattle,WA98195,USAcDepartmentofChe
3、micalandBiologicalEngineering,ZhejiangUniversity,Hangzhou,ChinadDepartmentofNanoengineering,UniversityofCalifornia,SanDiego,LaJolla,CA92093,USAarticleinfoabstractArticlehistory:Surfacecoatingsofhighpackingdensitieshavebeenroutinelyusedtopreventnonspecificbiomolecula
4、rReceived18May2012andmicroorganismattachment.HydrogelsareanotherclassoflowfoulingmaterialsusedtocreateAccepted17July2012three-dimensionalmatrixesforthefreediffusionofsmallanalytesordrugsandthehigh-loadingofbio-Availableonline3August2012recognitionelements.However,b
5、iomoleculesaresubjecttobeingentrappedwithinhydrogelmatrixesoradheredontohydrogelsurfaces,makingthemquestionableforuseinwholeblood.Here,wedemon-Keywords:stratethefeasibilityofalightlycrosslinkedpoly(carboxybetaine)hydrogelforuseinwholeblood,asZwitterionicoppositetot
6、heconventionalwisdomofhighpackingdensityinsurfacecoatings.ProteinsareabletoHydrogeldiffuseinandoutofthematrixfreelywithoutbeingalteredfromtheirnativeconformations.InordertoGlucoseBiosensordemonstrateitslong-termperformanceinwholeblood,thishydrogelwasusedasthesurfac
7、ecoatingofWholebloodaglucosesensor.Thisworkpavesanewwayforthedevelopmentofsurfacecoatingsandsensorstoachievelong-termstabilityandhighperformanceinwholeblood.Ó2012ElsevierLtd.Allrightsreserved.1.Introductiondensitiesassurfacecoatings(Fig.1b)inordertoeffectivelyresis
8、tfoulingincomplexmedia.Forexample,glucosesensorcoatedwithTodate,numerousmaterialsandcoatingssuchaspoly(ethylenepolyHEMAhydrogelwithadditionalepox
