资源描述:
《Ca2+-Dependent Transcription in Neurons》由会员上传分享,免费在线阅读,更多相关内容在行业资料-天天文库。
1、SnapShot:Ca2+-DependentTranscriptioninNeuronsJanineZieg,PaulL.Greer,andMichaelE.GreenbergDepartmentofNeurobiology,HarvardMedicalSchool,Boston,MA02115,USASeeonlineversionforlegendandreferences.AlsoseetheSeptember25,2008,NeuronReviewsIssue1080Cell134,September19,2008©2008ElsevierI
2、nc.DOI10.1016/j.cell.2008.09.010entitled“CalciumSignalingattheSynapse.”SnapShot:Ca2+-DependentTranscriptioninNeuronsJanineZieg,PaulL.Greer,andMichaelE.GreenbergDepartmentofNeurobiology,HarvardMedicalSchool,Boston,MA02115,USASynapticactivitystimulatestheinfluxofcalciumionsintothe
3、postsynapticneuronandtherebysetsinmotionacascadeofsignalingeventsthatleadtochangesingeneexpression.Thesechangesingeneexpressionaffectmanyaspectsofnervoussystemdevelopmentincludingdendriticmorphogenesis,neuronalsurvival,andsynapsedevelopmentaswellastheadaptiveresponsesthatunderli
4、elearningandmemoryinthematurenervoussystem.Mutationsincomponentsofthesignal-ingpathwaysthatparticipateintheprocessofexperience-dependentbraindevelopmenthavebeenfoundtogiverisetoavarietyofdisordersofcognitivefunctionincludingautismspectrumdisorders.Theinitialcontactbetweentheaxon
5、andthedendriteduringsynapsedevelopmentismediatedbycellsurface-associatedproteinsonthepre-andpostsynapticmembranes.Forexample,thebindingofpresynapticβ-neurexintoitspostsynapticreceptor,Neuroligin1,leadstotherecruitmentofPSD-95atnascentexcitatorysynapses.Ephrin/Ephsignalingleadsto
6、therecruitmentofadditionalproteinsandthepotentiationofNMDAreceptorsignaling.Releaseoftheexcitatoryneurotrans-mitterglutamatefromthepresynapticmembraneanditsbindingtoNMDAreceptorsandAMPAreceptorsonthepostsynapticmembraneleadtotheopeningoftheseglutamate-gatedionchannels.Thisisfoll
7、owedbymembranedepolarization,openingoftheL-typevoltage-gatedcalciumionchannel(L-VSCC),andarapidriseincalciumionsinthepostsynapticneuronaswellasotherlocalchangesincludingproteinrecruitmentandactivation.CalciumentrythroughL-VSCCsleadstotherecruitmentofAKAP79/150,whichthenrecruitsP
8、KAtothechannel.PKAphosphorylatesthecalciumchann