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1、PerspectiveTheRealityofPervasiveTranscription11.2.11MichaelB.Clark,PauloP.Amaral,FelixJ.Schlesinger,MarcelE.Dinger,RyanJ.Taft,JohnL.345678Rinn,ChrisP.Ponting,PeterF.Stadler,KevinV.Morris,AntoninMorillon,JoelS.Rozowsky,8910102MarkB.Gerstein,ClaesWahlestedt,YoshihideHa
2、yashizaki,PieroCarninci,ThomasR.Gingeras*,1JohnS.Mattick*1InstituteforMolecularBioscience,UniversityofQueensland,Brisbane,Queensland,Australia,2WatsonSchoolofBiologicalSciences,ColdSpringHarborLaboratory,ColdSpringHarbor,NewYork,UnitedStatesofAmerica,3BroadInstitute,
3、Cambridge,Massachusetts,UnitedStatesofAmerica,4MRCFunctionalGenomicsUnit,DepartmentofPhysiology,AnatomyandGenetics,UniversityofOxford,Oxford,UnitedKingdom,5DepartmentofComputerScience,UniversityofLeipzig,Leipzig,Germany,6DepartmentofMolecularandExperimentalMedicine,S
4、crippsResearchInstitute,LaJolla,California,UnitedStatesofAmerica,7InstitutCurie,UMR3244-PavillonTrouilletRossignol,Paris,France,8ComputationalBiologyandBioinformatics,YaleUniversity,NewHaven,Connecticut,UnitedStatesofAmerica,9UniversityofMiami,Miami,Florida,UnitedSta
5、tesofAmerica,10OmicsScienceCenter,RIKENYokohamaInstitute,Tsurumi-ku,Yokohama,Kanagawa,JapanCurrentestimatesindicatethatonlyPreviousEvidenceforPervasiveribosomalportionofthepolyA+transcrip-about1.2%ofthemammaliangenomeTranscriptiontome[7,8,10,14–19],normalizationap-co
6、desforaminoacidsinproteins.How-proacheswereusedtoreducethequantityever,mountingevidenceoverthepastTheconclusionthatthemammalianofhighlyexpressedtranscriptsinthesedecadehassuggestedthatthevastmajor-genomeispervasivelytranscribed(i.e.,cDNAanalyses[7,8],andareimplicitin
7、ityofthegenomeistranscribed,well‘‘thatthemajorityofitsbasesareassoci-tilingarrayapproaches.Thiswasneces-beyondtheboundariesofknowngenes,aatedwithatleastoneprimarytranscript’’sarytoallowthedetectionofrarer(oftenphenomenonknownaspervasivetran-[1])wasbasedonmultipleline
8、sofcelltype–restricted[1,13,16,19,20])tran-scription[1].Challengingthisview,anevidence.Bothlarge-scalecDNAsequenc-scripts.articlepu
