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1、IntegratedRegulationoftheTypeIIISecretionSystemandOtherVirulenceDeterminantsinRalstoniasolanacearum¤**MarcValls,Ste´phaneGenin,ChristianBoucherLaboratoiredesInteractionsPlantes-Microorganismes(CNRS-INRA),ChemindeBordeRouge,CastanetTolosanCedex,FranceInmanyplantandanimalbacteri
2、alpathogens,theTypeIIIsecretionsystem(TTSS)thatdirectlytranslocateseffectorproteinsintotheeukaryotichostcellsisessentialforthedevelopmentofdisease.Inallspeciesstudied,thetranscriptionoftheTTSSandmostofitseffectorsubstratesistightlyregulatedbyasuccessionofconsecutivelyactivated
3、regulators.However,thewholegeneticprogrammedrivenbytheseregulatorycascadesisstillunknown,especiallyinbacterialplantpathogens.Here,wehavecharacterisedtheprogrammetriggeredbyHrpG,ahost-responsiveregulatoroftheTTSSactivationcascadeintheplantpathogenRalstoniasolanacearum.Weshowthr
4、oughgenome-wideexpressionanalysisthat,inadditiontotheTTSS,HrpGcontrolstheexpressionofapreviouslyundescribedTTSS-independentpathwaythatincludesanumberofothervirulencedeterminantsandgeneslikelyinvolvedinadaptationtolifeinthehost.Functionalstudiesrevealedthatthissecondpathwayco-o
5、rdinatesthebacterialproductionofplantcellwall-degradingenzymes,exopolysaccharide,andthephytohormonesethyleneandauxin.Weprovideexperimentalevidencethattheseactivitiescontributetopathogenicity.WealsoshowthattheethyleneproducedbyR.solanacearumisabletomodulatetheexpressionofhostge
6、nesandcanthereforeinterferewiththesignallingofplantdefenceresponses.Theseresultsprovideanew,integratedviewofplantbacterialpathogenicity,whereacommonregulatoractivatessynchronouslyuponinfectiontheTTSS,othervirulencedeterminantsandanumberofadaptivefunctions,whichactco-operativel
7、ytocausedisease.Citation:VallsM,GeninS,BoucherC(2006)IntegratedregulationoftheTypeIIIsecretionsystemandothervirulencedeterminantsinRalstoniasolanacearum.PLoSPathog2(8):e82.DOI:10.1371/journal.ppat.0020082Ralstoniasolanacearumisab-proteobacteriumresponsibleIntroductionforbacter
8、ialwiltofover200plantspecies[14].PlantMostpathogenicbacteriaa
