ChildrenAsthm没上的

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1、ChildrenAsthmaMaLiandefinitionAsthmaisadiseaseofchronicinflammationandvaryingdegreesofseverityreplacingthatofitbeingadiseaseofreversibleairwayobstruction.What;WhoCharacteristic：AirwayhyperresponsivenessTheetilogy:Geneticbasisofadisease：Geneticfactors,predominantlyatopyandaparentalhistoryofa

2、sthma。AtopicdermatitisandasthmaTheetilogyenvironmentalfactors：Maternalsmokingandfamily(especiallymaternal)historyofatopyappeartoberiskfactorsforpersistentsensitizationanddevelopmentofasthma.Indeed,exposuretotobaccosmokeinuterosignificantlyincreasesasthmariskandinfluencesthetimingofsensitiza

3、tionTheetilogysensitizationandexposureto：Allergen:cockroaches,housedustmites,moldAlternariaalternata,TheetilogyOtheraeroallergens：weather:flower:TheetilogyOtheraeroallergens：feather:paint:makeupTheetilogyInfection:mycoplasmachlamydozoomTheetilogyViralrespiratoryinfectionsrespiratorysyncytia

4、lvirus:areasignificantriskfactorforthedevelopmentofchildhoodwheezinginthefirstdecadeoflife.TheepidemiologyAge：〈６year84.8%Boy:girl＞1.5:11988-1990Chinanationalsuivey：1.0%Tibet：0.11%FuJian：2.03%ShiChuan：1.95%GuangDong：0.9%Stantou：5.0%Theepidemiology1999：secondsuivey：adults：0.7%-1.5%；children：3

5、%-5%ChinaAsthma：10million－20millionWorldAsthma：150millionThepathogenesisAirwayinflammation（airwayallergicinflammation）：bothchronicinflammationandairwayremodelingaremorethanlikelytobeinvolvedinthedevelopmentandprogressionofasthmainthisyoungpopulation.Indeed,evidencesuggeststhatairwayrestruct

6、uringoccursearly.Theimplicationsfortreatmentinanydifferencesofinflammationandremodelingbetweenchildrenandadults,then,arelikelytobeimportantThepathogenesisinflammationcells：eosinophilcells、mastcells；ＩｇＥ；inflammationmediators；cytokines；neuropeptides；imbalanceordysregulationinTh1/TH1-typeimmun

7、ityDiagnosisInfantasthma：Childrenasthma:Coughvariantasthma：TherapyAntiinflammationtherapy:corticosteroidsareconsideredasfirst-lineanti-inflammatorytreatment,especiallyinchronicasthma.TherapyInhalectherapyTheuseofcorticosteroidsinsyntomathicasthmainchildh