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1、HindawiPublishingCorporationMediatorsofInflammationVolume2013,ArticleID390890,10pageshttp://dx.doi.org/10.1155/2013/390890ResearchArticleNaturalAntioxidant-IsoliquiritigeninAmelioratesContractileDysfunctionofHypoxicCardiomyocytesviaAMPKSignalingPathway1,234213XiaoyuZhang,PingZhu,XiuyingZ
2、hang,YinaMa,WenguangLi,Ji-MeiChen,3532Hui-MingGuo,RichardBucala,JianZhuang,andJiLi1InstituteofPhysiology,SchoolofBasicMedicineSciences,LanzhouUniversity,Lanzhou730000,China2DepartmentofPharmacologyandToxicology,SchoolofMedicineandBiomedicalSciences,UniversityatBuffalo-SUNYUniversityofNew
3、York,Buffalo,NY14214,USA3DepartmentofCardiovascularSurgery,GuangdongCardiovascularInstitute,GuangdongGeneralHospital,GuangdongAcademyofMedicalSciences,Guangzhou510080,China4DepartmentofEmergency,GansuProvincialHospital,Lanzhou730000,China5DepartmentofInternalMedicine,YaleUniversitySchool
4、ofMedicine,NewHaven,CT06520,USACorrespondenceshouldbeaddressedtoJianZhuang;zhuangjianzggd@yahoo.cnandJiLi;jli23@buffalo.eduReceived16July2013;Accepted14August2013AcademicEditor:FatihArslanCopyright©2013XiaoyuZhangetal.ThisisanopenaccessarticledistributedundertheCreativeCommonsAttribution
5、License,whichpermitsunrestricteduse,distribution,andreproductioninanymedium,providedtheoriginalworkisproperlycited.Isoliquiritigenin(ISL),asimplechalcone-typeflavonoid,isderivedfromlicoricecompoundsandismainlypresentinfoods,beverages,andtobacco.Reactiveoxygenspecies(ROS)isacriticalfactor
6、involvedinmodulatingcardiacstressresponsesignalingduringischemiaandreperfusion.WehypothesizethatISLasanaturalantioxidantmayprotectheartagainstischemicinjuryviamodulatingcellularredoxstatusandregulatingcardioprotectivesignalingpathways.ThefluorescentprobeH2DCFDAwasusedto3measurethelevelof
7、intracellularROS.Theglucoseuptakewasdeterminedby2-deoxy-D-glucose-Haccumulation.TheIonOptixSystemmeasuredthecontractilefunctionofisolatedcardiomyocytes.TheresultsdemonstratedthatISLtreatmentmarkedlyamelioratedcardiomyocytescontractiledysfunctioncausedbyhypoxia.ISLsignific
