Recent Advances in Novel Drug Delivery Systems

Recent Advances in Novel Drug Delivery Systems

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时间:2019-05-20

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1、RecentAdvancesinNovelDrugDeliverySystemsRecentAdvancesinNovelDrugDeliverySystemsCostasKaparissides,SofiaAlexandridou,KaterinaKottiandSotiraChaitidouCopyrightAZoM.comPtyLtd.ThisisanAZoOpenAccessRewardsSystem(AZo-OARS)articledistributedunderthetermsoftheAZo–O

2、ARShttp://www.azonano.com/oars.aspwhichpermitsunrestricteduseprovidedtheoriginalworkisproperlycitedbutislimitedtonon-commercialdistributionandreproduction.stSubmitted:July1,2005thPosted:March25,2006DOI:10.2240/azojono0111TopicsCoveredIntroductionDrugDeliver

3、ySystemsDrugDeliveryCarriersAdministrationRoutesFutureOpportunitiesandChallengesReferencesContactDetailsIntroductionThemethodbywhichadrugisdeliveredcanhaveasignificanteffectonitsefficacy.Somedrugshaveanoptimumconcentrationrangewithinwhichmaximumbenefitisder

4、ived,andconcentrationsaboveorbelowthisrangecanbetoxicorproducenotherapeuticbenefitatall.Ontheotherhand,theveryslowprogressintheefficacyofthetreatmentofseverediseases,hassuggestedagrowingneedforamultidisciplinaryapproachtothedeliveryoftherapeuticstotargetsin

5、tissues.Fromthis,newideasoncontrollingthepharmacokinetics,pharmacodynamics,non-specifictoxicity,immunogenicity,biorecognition,andefficacyofdrugsweregenerated.Thesenewstrategies,oftencalleddrugdeliverysystems(DDS),arebasedoninterdisciplinaryapproachesthatcom

6、binepolymerscience,pharmaceutics,bioconjugatechemistry,andmolecularbiology.Tominimizedrugdegradationandloss,topreventharmfulside-effectsandtoincreasedrugbioavailabilityandthefractionofthedrugaccumulatedintherequiredzone,variousdrugdeliveryanddrugtargetingsy

7、stemsarecurrentlyunderdevelopment.Amongdrugcarriersonecannamesolublepolymers,microparticlesmadeofinsolubleorbiodegradablenaturalandsyntheticpolymers,microcapsules,cells,cellghosts,lipoproteins,liposomes,andmicelles.Thecarrierscanbemadeslowlydegradable,stimu

8、li-reactive(e.g.,pH-ortemperature-sensitive),andeventargeted(e.g.,byconjugatingthemwithspecificantibodiesagainstcertaincharacteristiccomponentsoftheareaofinterest).Targetingistheabilitytodirectthedrug-

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