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ID:36685792
大小:3.46 MB
页数:58页
时间:2019-05-13
《胆囊癌临床病理学及转移机制的探讨》由会员上传分享,免费在线阅读,更多相关内容在学术论文-天天文库。
1、遵义医学院硕士学位论文胆囊癌临床病理学及转移机制的探讨姓名:彭慈军申请学位级别:硕士专业:病理学指导教师:邓飞2003.6.20遵义医学院硕士毕业论文胆囊癌临床病理学及转移机制的探讨第一部分胆囊癌的憔床病理分析摘要目的本文按照中华病理学肿瘤最新分类,研究了我省部分胆囊癌临床病理资料。以探讨胆囊癌的病理类型及临床特点。材料与方法收集包括本院在内的省内多家医院病理科1986-,2002年手术切除后病理诊断胆囊癌的42例标本及其相关的临床病理资料,所有标本均为10%福尔马林固定的石蜡包埋组织,行4IIm厚连续切片,常规HE染色及PAS染色,光镜下观察其病理组织形态结
2、构,并结合有关临床资料进行一定的综合分析。结果本组资料共42例,男性12例,女性30例,男女之比约为I:2:3,年龄3l~82岁,平均59.55岁。术前临床诊断为胆囊癌26例,误诊为其他胆道良性疾病16例,合并胆囊结石18例。病理检查有转移23例,无转移19例.按临床Nevin分期:早期癌lI例(NevinI~JJ期),巾晚期癌3l例(NevinlI卜V期)。按浸润深度:局限于藕膜层至浅肌层12例,浸润全层30例。有效随访8例:存活超过2年l例,超过1年l例,其余6恻存活时问均未过1年。病理组织分型:腺癌22例(52.38%),粘液腺癌6例(14.28%),肠
3、型腺癌5例(11.9J%),乳头状腺癌4例(9.5236),鳞癌2例(4.76%),印戒细胞癌2例(4.76%).透明细胞腺癌l例(239%)。在腺癌22例中.发生转移16例(72,72%),其它病理类型20例中,有转移7铡(35.oo%),二者比较有显著性差异(p4、arcinomaAbstractObjectiVesTheaimofthisstudyistoinvestigatethepathologicalclassificationandclinicalfeaturesofgallbladdercarcinomainGuizhouaccordingtothetumornewestclassificationofChinesePathologicalAssociation,lMaterialsandMethodsAIlclinicaldataof42casessufferingfromgallbladdercarcin5、omaweresummarized,whichwerecollectedfromtheDepatmentofPathology.inAffiliatedHospitalofZunyiMedicalCollegeandotherhospitals.Allsw.cimenshadbeenfixedinlO%neutralbufferedformalinandembeddedinpal'ffHn.S∞tionswefecut,andstainedwithHEandPASroutinely.MorphologicalstructuresWereobservedbyli6、ghtmicroscope.RetultaThe42patientsincluded12maleand30female..Theratioofmaletofemalewasabout1:2.3.Agerangedfrom32to82years,theaverageageWaS59.55years.Beforesurgicaloperation,26patientswerediagnosed髂gallbladdercarcinoma,and18asgallstone.Unluckly,16patientswerem/sdiagnosedasbenignlesio7、nofgallbladder,inwhich,metastasisin23patientsandno-metastasisin19patientswereallprovedbypathologicalexamination.AccordingtothestagesofNevin.1lpatientswereatNevein'sstageI.IL31patientsatNevien’Sstagelll-V.Thetumorcellsin12pafientswel-elimitedfromthelayerofmucosatothesuperficialmuscle8、’Slayer,andother30p
4、arcinomaAbstractObjectiVesTheaimofthisstudyistoinvestigatethepathologicalclassificationandclinicalfeaturesofgallbladdercarcinomainGuizhouaccordingtothetumornewestclassificationofChinesePathologicalAssociation,lMaterialsandMethodsAIlclinicaldataof42casessufferingfromgallbladdercarcin
5、omaweresummarized,whichwerecollectedfromtheDepatmentofPathology.inAffiliatedHospitalofZunyiMedicalCollegeandotherhospitals.Allsw.cimenshadbeenfixedinlO%neutralbufferedformalinandembeddedinpal'ffHn.S∞tionswefecut,andstainedwithHEandPASroutinely.MorphologicalstructuresWereobservedbyli
6、ghtmicroscope.RetultaThe42patientsincluded12maleand30female..Theratioofmaletofemalewasabout1:2.3.Agerangedfrom32to82years,theaverageageWaS59.55years.Beforesurgicaloperation,26patientswerediagnosed髂gallbladdercarcinoma,and18asgallstone.Unluckly,16patientswerem/sdiagnosedasbenignlesio
7、nofgallbladder,inwhich,metastasisin23patientsandno-metastasisin19patientswereallprovedbypathologicalexamination.AccordingtothestagesofNevin.1lpatientswereatNevein'sstageI.IL31patientsatNevien’Sstagelll-V.Thetumorcellsin12pafientswel-elimitedfromthelayerofmucosatothesuperficialmuscle
8、’Slayer,andother30p
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