谷氨酸结晶工艺优化研究与应用—间歇结晶过程的优化与连续结晶的探索

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1、江南大学硕士学位论文谷氨酸结晶工艺优化研究与应用—间歇结晶过程的优化与连续结晶的探索姓名：王正伟申请学位级别：硕士专业：发酵工程指导教师：毛忠贵20091201AbstraetAbstractInChina，“BatchIso-electronicandIon-Exchange”crystallizationiSmostlyemployedintheglutamateextractionintheindustryofmonosodiumglutamate．Somecompaniesalsouse“ConcentratedIso—electronicandCrystalTr

2、ansition”process．Using“BatchIso-Electronic”crystallization．theresidualconcentrationofglutamateinmotherliquorisupto2．0---2．6g／100mlandthefirstextractionrateismerely77---80％．Extractionratewilltotallyincreaseto94---95％withtheadditionalIon-Exchangetechnology．However,largeamountofacidandalkali

3、areconsumed．andhugewastewaterwithlOWconcemtrationofglutamicacidisproduced．“ConcentratedIso—Electric”processiseasytooperateandthequalityofcrystallineiSgoodifthecrystaltransformationtechniqueiScombinedwith．ButlargeinvestmentiSneeded，andextractionrateispoor,generallyonly86％．Therefore，thehigh

4、extractionrate，thegoodglutamatequalityandthelowresourcesconsumptionarethedevelopmentaldirectionofglutamicacidextractiontechnology．Inindustry，theoperationof“BatchIso—electronic’’crystallizationisunderasemi—scientificandsemi—empiricalstate．Theunevenqualityofcrystallineandtheinstabilityextra

5、ctionoftenaccompaniedwitllamountof13-glutamicacidinproduct，resultingingreateconomicalloss．Witllextractionrateandcrystallinequalityaskeyindicators，byelectronmicroscopy，MasterSizer2000laserparticlesizeanalyzer，andotheradvancedequipments，variousstrategiesofBatchIso-Electroniccrystallizationo

6、fglutamate，suchascrystalseedaddition，acidityadjugement，adoptionofhighconcentrationglutamicacideffluentfromion—exchangecolumn．etc．werestudied．Thescientificandeasy-to-operateprocessofbatchIso-Electroniccrystallizationwereestablished：12g／100mlofglutamatefermentationbroth，pH4．3，8％crystalseeds

7、(w／w)addition，maintenanceofpH4．3-pH3．7for8h，pH3．7-pH3．2for4h．Thecrystallinepuritywasupto96．8-97．4％andthefirstextractionrateupto84-84．4％．mentheconcentrationofglutamatefermentationbrothiS14．5g／100m1．goodglutamatewithcrystallinepurityaround97．3-97．4％Wasobtained．Thefirs