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时间:2019-03-08
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1、1.MinimumInhibitoryConcentration(MIC)isthelowestconcentrationofanantimicrobialthatwillinhibitthevisiblegrowthofamicroorganismafterovernightincubation.MICisgenerallyregardedasthemostbasiclaboratorymeasurementoftheactivityofanantimicrobialagentagainstanorganism.最低抑菌浓度(MIC):在体外培养细菌18-24h后能抑制培
2、养基内细菌生长的最低药物浓度.2.MinimumBactericidalConcentration(MBC)isthelowestconcentrationofantibioticrequiredtokillanorganism.矚慫润厲钐瘗睞枥庑赖。最低杀菌浓度(MBC):在体外试验中,能够杀灭培养基内细菌的最低药物浓度.3.Pharmacokinetics:whatthebodydoestothedrug聞創沟燴鐺險爱氇谴净。Pharmacodynamics:whatthedrugdoestothebody4.5.First-passmetabolismFirst-pa
3、sseffectorFirst-passeliminationAphenomenonofdrugmetabolismwherebytheconcentrationofadrugisgreatlyreducedbeforeitreachesthesystemiccirculation.残骛楼諍锩瀨濟溆塹籟。某些药物首次通过肠壁或经门静脉进入肝脏时被其中的酶所代谢致使进入体循环的药量减少的一种现象6.BioavailabilityAmeasurementoftheextentofatherapeuticallyactivedrugthatreachesthesystemicci
4、rculationandisavailableatthesiteofaction.酽锕极額閉镇桧猪訣锥。oneoftheprincipalpharmacokineticpropertiesofdrugs彈贸摄尔霁毙攬砖卤庑。经任何给药途径给予一定剂量的药物后到达全身血液循环内药物的百分率7.Areaundertheconcentration/timecurve(AUC)Themostreliablemeasureofbioavailability.Directlyproportionaltothetotalamountofunchangeddrugthatreachesth
5、esystemiccirculation.謀荞抟箧飆鐸怼类蒋薔。Calculatingtherelativeefficiencyofdifferentdrugproducts厦礴恳蹒骈時盡继價骚。血药浓度-时间曲线下面积:血药浓度随时间变化的积分值,与吸收后进入体循环的药量成正比,反映进入体循环药物的相对量茕桢广鳓鯡选块网羈泪。8.9.Apparentvolumeofdistribution(VD) Apharmacologicaltermusedtoquantifythedistributionofamedicationthroughoutthebodyafteroral
6、orparenteraldosing Itisdefinedasthevolumeinwhichtheamountofdrugwouldneedtobeuniformlydistributedtoproducetheobservedbloodconcentration A∕Co鹅娅尽損鹌惨歷茏鴛賴。当血浆和组织内药物分布达到平衡后,体内药物按此时的血浆药物浓度在体内分布时所需体液容积称表观分布容积 10.ForcedExpiratoryVolumein1second(FEV1) Themaximumvolumeofairthatcanbeexpiredfromthelung
7、sinthefirstsecondwhenstartingfrommaximuminspiration 籟丛妈羥为贍偾蛏练淨。11.ForcedVitalCapacity(FVC) Themaximumvolumeofairthatapersoncanexhaleaftermaximuminspiration 第1秒用力呼气量(FEV1):尽力最大吸气后再尽力尽快呼气,在第1秒钟内呼出的气量. 用力肺活量(FVC):尽力最大吸气后再尽力尽快呼气所能呼出的最大气量.預頌圣鉉儐歲龈讶骅籴。12.PeakExpirato
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