低频脉冲超声治疗膝骨关节炎疗效分析

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1、低频脉冲超声治疗膝骨关节炎疗效分析唐进黄良库徐西东陈世荣重庆医科大学附属第二临床学院骨科400016摘要：目的观察低频脉冲声对膝骨关节炎（KOA）的疗效。方法总结2009年6月至2010年6月门诊和住院按疗程治疗的膝关节骨关节炎患者186例。根据病人的意愿或经济情况分为低频脉冲超声加口服药治疗组（A组）66例、单纯低频脉冲超声治疗组（B组）60例和口服药物组(C组，口服西乐葆)60例。三组在年龄及性别等方面无明显差异。对比观察三组患者治疗前和治疗8周后的VAS评分、Lequence评分、关节液炎症介质指标（IL-1；MMP-9）。结果治疗8周后，A组、各项观察指标均

2、有明显改善，与B组、C组比较差异具有显著性（p<0.01），B组和C组比较差异没有显著性（p>0.05）。结论低频超声治疗骨关节炎可明显减轻关节局部的症状，缓解关节肿胀，增加关节的活动度，减轻关节炎症，疗效与单用口服药物相当，低频超声加口服药物治疗优于单纯低频超声治疗和单纯口服药物治疗，提示二者有协同作用。关键词：低频脉冲超声；膝骨关节炎；VAS评分；Lequence评分；IL-1；MMP-9Effectoflow-frequencypulsedultrasoundontreatmentofkneeosteoarthritisTANGJin,Departmentof

3、Orthopedics,TheSecondAffiliatedHospitalofChongqingMedicalUniversity,Chongqing400016，ChinaAbstract:Objective:Toobservetheefficacyoflow-frequencypulsedultrasoundtreatmentonkneeosteoarthritis(KOA).Methods:Summarywasmadeofthe186out-patientandin-patientcaseswiththerapeuticcourseoftreatmentf

4、romJune2009toJune2010.Accordingtothewishesoreconomicconditionsofthepatients,186casesweredividedintothe3groups:66cases(groupA：low-frequencypulsedultrasoundtreatmentplusoralCelecoxib),60cases(groupB：simplelow-frequencypulsedultrasoundtreatment)and60cases(groupC：oralCelecoxib).Therewasnoo

5、bviousdifferenceinsuchaspectsasageandsexinthethreegroups.ComparisonwasmadeabouttheVASscore,Lequencescore,andsynovialfluidinflammatoryindicators(IL-1;MMP-9)beforetreatmentandeightweeksaftertreatment.Results:Afterthetreatmentforeightweeks,observationindexofgroupAwereimprovedsignificantly

6、.Thedifferencewassignificant(p<0．01)withgroupBandgroupC;andthedifferencewasnotsignificantbetweengroupBandgroupC（p>0.05）.Conclusion：Thisstudyshowsthatforthepatientswithosteoarthritisoftheknee，thelow-frequencyultrasoundtreatmentcansignificantlyreducethesymptomsofjointpain,increasejointac

7、tivities,easethejointswellingandrelievearthritis;Andthecurativeeffectisequaltotheuseoftheoralmedicineseparately.Low-frequencyultrasoundtreatmentplusOralmedicineissuperiortosimplelow-frequencyultrasoundtreatmentandthesingleoralmedicine,andsuggestingasynergisticeffectbetweenthetwo.Keyw