黄芪甲苷治疗糖尿病骨折的实验分析与临床初步应用

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1、AbstractobjectiveToexploreinnovationinthetreatmentoffracturethroughanexperimentalresearchandpreliminaryclinicalobservationbyAstragaloside．Metho．dsPart1：seventy-twomaleSDratswererandomlydividedintothreegroupsGroupAwasDiabetesAstragaiosidetreatmentgroup，GroupBwasnon-treatmentDiaberes

2、group，GroupCwaseontrolgroup．IngroupAandBstreptozotocinwasinjectedintotheirabdominalcavitiestomakediabetesmeuitusmodel，ingroupCequivalentsterilizedsalinewasinjected．Fracturemodelwasmadeinfemurandreductedandinternalfixed．TheXraysoffemurtakeninthethreegroupsin6th,8thweeksafterthesurge

3、rytoevaluationthefracturehealing．6、8weeksafterfracture，5ratsweresacrificedineachgrouptoobservedthegroupofcallus，thetissueoffractureregionwastakenforHEstaining．At6thand8thweekafteroperationbiomechanicaltestwasdone．AllthedatawasprocessedbytheSPSS17．0statisticalpackage．Part2：Thedataof

4、15caseswithlimbsfracturetreatedwithAstragalosideretrospectivelyanalysed，andtheefficacywasevaluated．ResultsPart1：AntomicobservationshowedthateverytimepointgroupBcallusgrowthwasslower,therewasnosignificationdiffererncebetweengrougAandC．Thereweremoreperiostealreactionandrapidbonerecon

5、structioningroupAandCthaningroupB．Thediabeticcallusmechanicalstrengthwassignificantlylowerthanincontrolgroupandastragalosidetherapygroup．HEstainingsuggestedthechondrocytematurationhysteresisandhypertrophyindiabeticrats．Part2：Allcaseswerefollowedupfor6to12monthsandwerebonehealing．Th

6、eaveragehealingtimewas5．2monthsConclusionAstragalosidecouldovercomethenegativeeffectofdiabeticfracturehealing，andrecoverabilityofnormalfracturehealing．Astragalosidecouldpromotediabeticfracturehealing．Keywords：Diabetesmellitus，Fracturehealing，AstragalosideV黄芪甲苷治疗糖尿病骨折的实验研究及临床初步应用．j上

7、．JL刖吾糖尿病属中医消渴范畴，是一种慢性、终身性疾病，会导致多种急慢性并发症，严重危害患者是身体健康和生活质量。糖尿病合并骨折是糖尿病严重并发症之一，在糖尿病患者的各种并发症中的发病率较高。中医认为糖尿病合并骨折属于“骨萎”、“消渴”的范畴。从脏腑病机而论，消渴以‘肾虚为本，脾虚是消渴发生发展的重要病机。三消中，无论有否脾胃症状，其病机转归以脾虚为主。脾气虚弱，脾的传输功能失常，使体内产生一系列病理变化，导致相关脏腑功能失调及阴阳失调。糖在人体处于十分重要的位置，作为能量参与人体一切代谢活动，像气血一样，是生命中不可或缺的物质，属于脾收纳水谷转化为精微物质

8、的一类。消渴病患者，由于脾虚，脾运功能出现问题，致使