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1、ThispageintentionallyleftblankIntroductiontoComputationalGenomicsWheredidHIVandSARScomefrom?HaveweinheritedgenesfromNeanderthals?Howdoplantsusetheirinternalclock?Howdoodorreceptorsfunction?Thege-nomicrevolutioninbiology,startedinthelate1990s,enablesustoanswersuchques
2、tions.Buttherevolutionwouldhavebeenimpossiblewithoutthesupportofpowerfulcomputationalandstatisticalmethodsthatenableustoexploitthemas-siveamountsofgenomicdata.Accordingly,manyuniversitiesareintroducingthecoursestotrainthenextgenerationofbioinformaticians:biologistswh
3、oarefluentinthelanguageofmathematicsandcomputerscience,anddataanalystswhoarefamiliarwiththeproblemsandtechniquesofbiology.Theentrycostintothisfieldisveryhigh,requiringknowledgeofseveraldisciplinesandofalargeandfast-growingliterature.Studentsneedaroadmaptonavigateentryt
4、othisfield.Thisreadableandentertainingbook,basedonsuccessfulcoursestaughtattheUniversityofCaliforniaandelsewhere,providesthat.Itguidesthereaderstepbystepthroughsomeofthekeyachievementsofbioinformatics.Thehands-onapproachmakeslearningeasierandexperimentationnatural,asw
5、ellasequippingthereaderwiththenecessarytoolsandskills.Statisticalsequenceanalysis,sequencealignment,hiddenMarkovmodels,geneandmotiffinding,geneexpressiondataanalysisandreconstructionofevolutionaryrelationsbetweengenomesareallintroducedinarigorousyetac-cessibleway.Acom
6、panionwebsiteprovidesthereaderwithallthedatausedintheexamples,linkstopubliclyavailablesoftware,andMatlabTMdemonstrationforreproducingandadaptingallthestepsperformedinthebook.NelloCristianiniisProfessorofArtificialIntelligenceattheUniversityofBristol.MatthewHahnisAssi
7、stantProfessor,DepartmentofBiologyandSchoolofInfor-matics,IndianaUniversity.IntroductiontoComputationalGenomicsACaseStudiesApproachNelloCristianiniandMatthewW.HahncambridgeuniversitypressCambridge,NewYork,Melbourne,Madrid,CapeTown,Singapore,SãoPauloCambridgeUniversit
8、yPressTheEdinburghBuilding,Cambridgecb22ru,UKPublishedintheUnitedStatesofAmericabyCambridgeUniversityPress,NewYorkwww.cambridge.org
