美容用聚合物微针的微注塑成型及其制品测试

美容用聚合物微针的微注塑成型及其制品测试

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页数:80页

时间:2019-03-03

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1、ABSTRACTMICRo.INJECTIoNMOLDINGANDPRoDUCTSTESTINGFORCoSMETICPOLYMERMICRO.NEEDLEMicro.needleiSanewadministrationmodebetweentransdermalpatchandsubcutaneousinjection,whichcanbefastandpainless,andcantransfermacromoleculardrugs.Polymermicro—needlehasawiderangeofoptionaimateria

2、ls,goodbiologicalcompatibilityandlowcost,issuitableformassproduction.Inthispaper,solidpolymermicro-needleasaresearchobject,numericalsimulationwascarriedoutwithANSYS.Injectionmoldingprocessofmicro-·needlewassimulatedbyMoldflow;PCmicro--needlewaspreparedbymeansofmicro-inje

3、ction,andinjectionmoldingprocessWasanalyzedbyorthogonalexperiment.Finally,theperformanceofPCmicro-needleWasverifiedinvitrotransdermalexperiment,specificstudiesareasfollows:(1)Themechanicalcalculationofmicro—needleWasperformed.ThestressofthreegroupsofPCmicro-needlewithdif

4、ferentsizeWassimulatedbyANSYS,thestressandstrainofmicro—needlewhenitpiercingtheskinWasinvestigated.Finally,theconicneedlestructureWasdeterminedunderⅡI北京化工大学硕士学位论文micro-injectionconditions,thetipdiameterwas30pro,bottomdiameterwas100l,tmandheightis350肿n.Toverifythefeasibil

5、ityofpolymermicro—needleintheory,thestrengthofPC,PMMA,PSandPLAmicro·needlewasverified.(2)InjectionmoldingprocessofPCmicro—needlewassimulatedwimMoldflow,theeffectoftherunnerandmoldcavitystructureonproductperformancewasanalyzed,thesimulationresultsshowthatproductswithsingl

6、erunnerstructurehadthebestperformance.Micro。needlewithrectangularandcirculararrayhadnoobviousdifferenceofinfluenceonthemoldingprocessandtheproducts.(3)PCmicro—needlewaspreparedbymeansofmicro—injection,andtheprocessparameterswereobtained.Fourfactors,includinginjectionspee

7、d,injectionpressure,melttemperatureandpackingpressure,threelevelsorthogonaltestwasfinished.Theresultsshowthatthemostimportantfactortoaffectingthequal毋ofproductsWaSmelttemperature;thesecondWastheinjectionspeed;injectionpressureandholdingpressurewereweakest.(4)Thestrengtho

8、fPCmicro—needlewasverifiedinvitrotransdermalexperimenttoensureitcouldbepiercedintotheskinwithoutbreakin

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