美容用聚合物微针的微注塑成型及其制品测试

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1、ABSTRACTMICRo．INJECTIoNMOLDINGANDPRoDUCTSTESTINGFORCoSMETICPOLYMERMICRO．NEEDLEMicro．needleiSanewadministrationmodebetweentransdermalpatchandsubcutaneousinjection，whichcanbefastandpainless，andcantransfermacromoleculardrugs．Polymermicro—needlehasawiderangeofoptionaimater

2、ials，goodbiologicalcompatibilityandlowcost，issuitableformassproduction．Inthispaper,solidpolymermicro-needleasaresearchobject，numericalsimulationwascarriedoutwithANSYS．Injectionmoldingprocessofmicro-·needlewassimulatedbyMoldflow；PCmicro--needlewaspreparedbymeansofmicro-

3、injection，andinjectionmoldingprocessWasanalyzedbyorthogonalexperiment．Finally,theperformanceofPCmicro-needleWasverifiedinvitrotransdermalexperiment,specificstudiesareasfollows：(1)Themechanicalcalculationofmicro—needleWasperformed．ThestressofthreegroupsofPCmicro-needlew

4、ithdifferentsizeWassimulatedbyANSYS，thestressandstrainofmicro—needlewhenitpiercingtheskinWasinvestigated．Finally,theconicneedlestructureWasdeterminedunderⅡI北京化工大学硕士学位论文micro-injectionconditions，thetipdiameterwas30pro，bottomdiameterwas100l，tmandheightis350肿n．Toverifythe

5、feasibilityofpolymermicro—needleintheory,thestrengthofPC，PMMA，PSandPLAmicro·needlewasverified．(2)InjectionmoldingprocessofPCmicro—needlewassimulatedwimMoldflow,theeffectoftherunnerandmoldcavitystructureonproductperformancewasanalyzed，thesimulationresultsshowthatproduct

6、swithsinglerunnerstructurehadthebestperformance．Micro。needlewithrectangularandcirculararrayhadnoobviousdifferenceofinfluenceonthemoldingprocessandtheproducts．(3)PCmicro—needlewaspreparedbymeansofmicro—injection，andtheprocessparameterswereobtained．Fourfactors，includingi

7、njectionspeed，injectionpressure，melttemperatureandpackingpressure，threelevelsorthogonaltestwasfinished．Theresultsshowthatthemostimportantfactortoaffectingthequal毋ofproductsWaSmelttemperature；thesecondWastheinjectionspeed；injectionpressureandholdingpressurewereweakest．(

8、4)ThestrengthofPCmicro—needlewasverifiedinvitrotransdermalexperimenttoensureitcouldbepiercedintotheskinwithoutbreakin