碧萝芷pycnogenol(

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1、碧蘿芷Pycnogenolâ能有效改善第II型糖尿病患者血糖濃度PycnogenolâDose-DependentlyLowersglucoseinType2DiabeticPatientsDiabeteshasalreadyincreasedbyone-thirdduringthe1990s,duetotheprevalenceofobesityandanageingpopulation.Theworldwidenumbersareexpectedtoclimbfrom194millionpeopletomorethan333milliondiabeticsby2025,accord

2、ingtotheInternationalDiabetesFederation.Foodandsupplementmakersareincreasinglylookingatwaystohelptoslowtheonsetofthedisease.ApromisingproductinthiscontextisPycnogenolâ.Pycnogenolâ,astandardizedextractfromthebarkoftheFrenchmaritimepine(PinuspinasterAit.),consistsofaconcentrateofphenoliccompoundsa

3、scatechin,taxifolin,procyanidinsandphenolicacids.Pycnogenolâisusedworld-wideasadietaryfoodsupplementandprovidesdiversebeneficialeffectsrelevantforpatientswithdiabetesmellitus.Thewelldocumentedradicalscavengingactivityanditsabilitytostimulatethesynthesisofantioxidativeenzymescontributestoreduceth

4、eoxidativestressindiabetics.AnimalexperimentsdemonstratedtheglucoseloweringeffectofPycnogenolâ(2).Simultaneously,antioxidativeenzymeswerefoundinlargerquantitiesinbloodoftheanimal(2).Thatenforcementofantioxidativedefensecouldalsobeobservedinhumanvolunteers.Pycnogenolâsupplementationincreasedtheac

5、tivityofbloodtoinactivatefreeradicals(3).Diabeticpatientshaveahigherriskofatherosclerosis,becauseofdisturbedlipidmetabolism.Pycnogenolâ,loweringthe"bad"cholesterolLDLandenhancingthegoodcholesterolHDL(3,4,5)helpstoreducetheriskofatherosclerosis.Diabeticpatientshaveahighriskforthrombosis.Thefactth

6、atPycnogenolâpreventstheclumpingofbloodplatelets(6,7)andpreventsthrombusformation(8)pointstoanimportantbenefitfordiabeticpatients.BesidethatcombinationofpotentiallypreventiveeffectsPycnogenolâhasbeenfoundtobeeffectiveintreatmentofdiabeticretinopathy(9).Personalverbalcommunicationsfrompatientsrep

7、ortingnoneedofinsulintreatmentfollowingthesupplementationwithPycnogenol®gavethereasontoinitiateaclinicalstudytoinvestigatewhetherPycnogenol®hasaglucoseloweringeffect.Theclinicalinvestigationwasdesignedasadose-findingstudy,te