肝肾康治疗乙型肝炎病毒相关性肾炎脾肾亏虚、湿毒浸蕴型的临床疗效观察

《肝肾康治疗乙型肝炎病毒相关性肾炎脾肾亏虚、湿毒浸蕴型的临床疗效观察》由会员上传分享，免费在线阅读，更多相关内容在学术论文-天天文库。

1、提要目的：观察肝肾康治疗乙型肝炎病毒相关性肾炎的临床疗效，探讨肝肾康治疗本病的相关机制，为临床上进一步改良及推广该配方提供试验及理论基础。方法：本研究收集乙型肝炎病毒相关性肾炎(经肾活检病理确诊)符合中医脾肾亏虚，湿毒浸蕴型诊断标准者共50例，并随机分为试验组和对照组各25例。对照组予抗病毒、控制血压、降蛋白尿等西医基础治疗，试验组在西医基础治疗上加用肝肾康，疗程为二个月。观察比较两组患者临床症状、体征及实验室检查指标的变化，并对症状及体征进行量化评分，作出疗效评价。结果：1、治疗前两组中医症状体征

2、积分无差异；治疗后经中医量化评分：试验组显效率56%、有效率36%，总有效率92%，对照组显效率28%、有效率44%，总有效率72%；试验组与对照组患者中医症状体征积分自身治疗前后比较均有显著差异（p＜0.01）；治疗后中医症状体征积分组间比较有显著性差异（p＜0.01），试验组优于对照组。2、试验组和对照组在提高乙型肝炎病毒相关性肾炎缓解率方面无显著性差异（p＞0.05）。3、试验组在降低蛋白尿、升高血清白蛋白方面优于对照组，差异有统计学意义（p＜0.05）。结论：肝肾康治疗乙型肝炎病毒相关性肾炎

3、（脾肾亏虚，湿毒浸蕴型），能改善患者肢体困重、食少纳呆、倦怠乏力、腰膝酸软、口干口苦等临床表现，从而显示出治疗本病的优势。关键词肝肾康；乙型肝炎病毒相关性肾炎；脾肾亏虚，湿毒浸蕴型ClinicalstudyonhepatitisBvirusassociatedglomerulonephritisofspleenandkidneydeficiencyandwetandpoisonattackwiththedecoctionofgan-shen-kangSpeciality:KidneyDisease,

4、NephropathyMedicineofTCMAuher:SunXiaoweiTutor:Prof.MiJieAbstractObjective:Toinvestigatetheeffectofgan-shen-kangpowdertreatinghepatitisBvirusassociatedglomerulonephritisofspleenandkidneydeficiencyandwetandpoisonattackonthebasisofwesternmedicinetreatment

5、.ToexplorethemechanismofcombiningtraditionalChineseandwesternmedicinetreatinghepatitisBvirusassociatedglomerulonephritisandlaythefoundationforfurtherimprovement.Methods:50patientswithhepatitisBvirusassociatedglomerulonephritisofspleenandkidneydeficienc

6、yandwetandpoisonattackweredividedinto2groupsatrandom,eachgroupis25cases.Thecontrolgroupweretreatedwithbasicmedicine,whiletheexperimentaltreatmentgroupweretreatedwithbasicmedicineandthedecoctionofgan-shen-kang.Thecourseoftreatmentis2months.Wewouldobserv

7、ethesubjectsoflaboraryexaminationbeforeandafterexperiment,recordedthechangeofpatients'clinicalsymptoms,atlastobservedthecurativeeffects.Results:1、Thereisnodifferenceinthetwogroupsofclinicalsymptomsbeforetreatment;hepatitisBvirusassociatedglomerulonephr

8、itisChinesequantitativescore:Theobviouslyeffectiveratioofexperimentalgroupis56%,theeffectiveratio36%,thetotaleffectiveratiois92%,thetotaleffectiveratioofcontrolgroupis60%;therewasasignificantdifferencesymptomsandsignsoftheexperimentalgr