阻塞性睡眠呼吸暂停综合征患者血浆血管内皮生长因子浓度测定

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1、维普资讯http://www.cqvip.com第l2400卷4第年l73月期中国现代医学杂志Vo1．14No．13ChinaJournalofModernMedicineJu1．2Oo4文章编号：1005—8982(2004)13—0045—04·论著·阻塞性睡眠呼吸暂停综合征患者血浆血管内皮生长因子浓度测定王艳姣，杨宇，张湘瑜，傅柳英(中南大学湘雅二医院老年内科，湖南长沙410011)摘要：目的探讨伴有不同程度夜间缺氧血症的阻塞性睡眠呼吸暂停综合征(Obstructivesleepapneasyndrome，OSAS)患者血浆血管内皮生因子(vascl1l

2、arendothelialgrowthfactor，VEGF)浓度的变化。方法40例经多导睡眠图(polysorrmography，PSG)检查诊断为OSAS的患者，根据夜间缺氧程度分为2组(重度夜间缺氧组和非重度夜间缺氧组)，每组各20例。清晨空腹采用检测血浆VEGF浓度。结果重度夜间缺氧组血浆VEGF浓度为(125．96±99．04)pg／ml，而非重度夜间缺氧组血浆VEGF浓度为(49．83±17．16)pg／ml，二者之间有显著差异。血浆VEGF浓度与夜间缺氧程度呈正相关(r=0．743，P<0．01)。结论重度夜间缺氧的OSAS患者血浆VEGF浓度明

3、显升高，OSAS患者夜间缺氧的严重程度呈血浆VEGF浓度正相关。关键词：睡眠呼吸暂停综合征；阻塞性；血管内皮生长因子；多导睡眠图；经皮血氧饱和度中图分类号：R．766．43文献标识码：AIncreasedlevelofvascularendothelialgrowthfactorinobstructivesleepapneasyndromewithseverenocturnalhypoxiaWANGYan-jiao，YANGYu，ZHANGXiang-yu，FULiu-ying(DepartmentofGeriatrws，theSecondXiangyaHos

4、pital，CentralSouthUniversity,Changsha,Hunan410011，P．R．China)Abstract：Objective：ToinvestigatetherelationshipbetweenthelevelofplasmaVasC~arendothelialgrowthfactor(VEGF)andtheseveritydegreeofobstructivesleepapneasyndrome(OSAS)．Methods：F0nypatientswithOSASwereevaluatedbypolysomnographyd

5、uringsleep．TheconcentrationofplasmaVEGFWasmeasuredbyELISAinsamplesobtainedfromtheantecubitalveinat7a．m．Results：PatientswitllseverenighttimehypoxiahadsignificantlyhigherplasmaVEGFlevelscomparedwithmildtomoderatenighttimehy—poxiaones[(154．96~99、04)pg／ndversus(49．83~17．16)pg／m1]．Thedeg

6、reeofnocturnaloxygendesaturationinOSASWassignificantlycorrelatedwithplasmaVEGFlevel(，=0．743，P<0．01)．Conclusion：TheplasmalevelofVEGFiselevatedinOSASpatientswithseverehypoxiaandrelatedtotheseveritydegreeofnocturnaloxygendesaturation．Keywords：obstructivedeepapneasyndrome；vascularendoth

7、elialgrowthfactor；,polysomnography；SpO2CLCnumber-"R766．43Documentcode：AObstructivesleepapneasyndrome(OSAS)isandmortality．TheSleepHeartHealthStudyassociatedwithincreasedcardiovascularmorbidityshowedthattheriskofcardiovasculardiseasedidReceiveddate：Dec．tO，2003}Thisworkwassupportedbygr

8、antsfromHunanProvin