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ID:33410081
大小:2.58 MB
页数:39页
时间:2019-02-25
《ki-67蛋白在年轻胃癌患者中的表达及预后分析》由会员上传分享,免费在线阅读,更多相关内容在学术论文-天天文库。
1、南昌大学硕士学位论文Ki--67蛋白在年轻胃癌患者中的表达及预后分析姓名:余静容申请学位级别:硕士专业:肿瘤学指导教师:熊建萍201206摘要IIIIIIIIIUllIIIIIIIIllIIIY2157676目的:本研究探讨Ki.67蛋白在年轻胃癌患者中的表达及意义。方法:回顾分析我院2005年1月.2009年12月期间经手术或内镜确诊的125例40岁及以下的年轻胃癌患者。病理组织蜡块采用免疫组化染色Envision法检测Ki.67蛋白表达,细胞增殖百分比采用Ki.67标记指数(Ki.67LI)量化,并观察Ⅺ.67标记指数与临床病理参数及与患者生存之间的关系。结果:
2、飚.67LI与患者性别、Lauren分型、组织分化程度、肿瘤侵犯深度、淋巴结转移、远处转移等临床病理特征密切相关(P值均3、生存,且飚.67是影响年轻女性胃癌患者生存的独立预后因素。关键词:胃癌;鼬.67标记指数(Ki.67LI):预后AbstractABSTRACTObjectives:WedesignedthisstudytoassessedKi.67proteinexpressioninyoungpatientswithgastriccancer.Methods:onehundredandtwentyfivecasesofgastriccancerinpatients40。years。oldandyounger,occurringintheperiodJanuary2001toJa4、nuary2006arereviewed.Thepathologic_aldiagnosisofthesepatientswasconfirmedbysurgcryandendoscopy.Gastriccancertissuefrom125patientswasimmunohistostainingforKi·67protein.Ki一67LabelindexwasdefinedasthepercentageoftumorcellspositiveforKi·67protein.TherelationshipbetweenKi.67LIandclinicopath5、ologicparameters,patientoverallsurvivalweresought.Results:Ki-67L1wascorrelatedwithgender,Histologictype,Laurenclassification,Tstage,Lymphaodemetastasis,Distantmetastasis(尸<0.001).Inyounggastriccancer,theHighLIgroupswerefoundtohaveasignificantlyworsemediansurvivaltimethanthelowLIgroups(6、尸7、ticfactorforsulvivalinyoungfemalepatientswithgastriccancer(HR=2.545,95%CI(1.198~5.405).P=0.015、.Conclusions:Ki-67LIisaneffectivetoolforpredictingsurvivalinyounggastriccancer,especiallyisallindependentprognosticfactorinyoungfemalepatientswithgastriccancer.Keywords:Gastriccancer;Ki-67l
3、生存,且飚.67是影响年轻女性胃癌患者生存的独立预后因素。关键词:胃癌;鼬.67标记指数(Ki.67LI):预后AbstractABSTRACTObjectives:WedesignedthisstudytoassessedKi.67proteinexpressioninyoungpatientswithgastriccancer.Methods:onehundredandtwentyfivecasesofgastriccancerinpatients40。years。oldandyounger,occurringintheperiodJanuary2001toJa
4、nuary2006arereviewed.Thepathologic_aldiagnosisofthesepatientswasconfirmedbysurgcryandendoscopy.Gastriccancertissuefrom125patientswasimmunohistostainingforKi·67protein.Ki一67LabelindexwasdefinedasthepercentageoftumorcellspositiveforKi·67protein.TherelationshipbetweenKi.67LIandclinicopath
5、ologicparameters,patientoverallsurvivalweresought.Results:Ki-67L1wascorrelatedwithgender,Histologictype,Laurenclassification,Tstage,Lymphaodemetastasis,Distantmetastasis(尸<0.001).Inyounggastriccancer,theHighLIgroupswerefoundtohaveasignificantlyworsemediansurvivaltimethanthelowLIgroups(
6、尸7、ticfactorforsulvivalinyoungfemalepatientswithgastriccancer(HR=2.545,95%CI(1.198~5.405).P=0.015、.Conclusions:Ki-67LIisaneffectivetoolforpredictingsurvivalinyounggastriccancer,especiallyisallindependentprognosticfactorinyoungfemalepatientswithgastriccancer.Keywords:Gastriccancer;Ki-67l
7、ticfactorforsulvivalinyoungfemalepatientswithgastriccancer(HR=2.545,95%CI(1.198~5.405).P=0.015、.Conclusions:Ki-67LIisaneffectivetoolforpredictingsurvivalinyounggastriccancer,especiallyisallindependentprognosticfactorinyoungfemalepatientswithgastriccancer.Keywords:Gastriccancer;Ki-67l
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