雷公藤口服液对股骨骨折愈合影响的初步临床观察-(6236)

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1、万方数据Abstractobjective：TheclinicalresearchwastoinvestigatetheeffectsofLeigongtengoralsolutiononfemurbonehealingMethods：InaprospectivestudyfromJune2013toJune2014，sixty-onepatientswhosufferedfromfemoralfractureswererandomlydividedintocontrolgroupwith30patientsandexperimentalgroupw

2、ith31patients．Leigongtengoralsolution(20ml／day)orsaline(20ml／day)Wasadministeredtothepatientsofassignedgrouporallyfor4weeks．At1，3，and12monthsaftersurgery,X-raywasusedtoassessthedifferenceofcallusgrowth,mineralizationvolume，callusdensityandthestateoffracturehealingbetweenthetwog

3、roups．Theresultswerepresentedasmean士SEMandanalyzedbySPSS18．0forwindows．AnyvalueofPlessthan0．05wereconsideredstatisticallysignificant．Results：ThereWasnosignificantdifferencewithrespecttofracturetype，thedurationofoperation，andamountofbloodloss，postoperativecomplicationsandfollow-

4、upperiod．At3，and6monthsaftersurgery,theresultsofX—rayevaluationshowedthatexperimentalgrouphadhigherscore(1．42土0．21，2．92土0．25，3．72土0．27)thancontrolgroup(0．82_40．19，2．36+0．23，3．15+0．28)，withasignificantdifference(P<0．01)．Besides，theresultsofX-raydemonstratedthatexperimentalgrouph

5、admarkedhighermineralizationvolume(80．45士6．82，160．25+8．16，250．35+9．94)．callusdensity(O．42士0．02，0．51+0．03，0．67+0．04)thanthoseincontrolgroup(41．1515．67，90．35：1：7．94，140．35士8．84；0．37士0．02，0．42--t：0．02，0．48+0．03)at1，3and6monthsaftersurgery．However,thehealingtimeofexperimentalgroup(

6、90．6+8．3)Wasshorterthanthatincontrolgroup(99．4+9．7)．withasignificantdifferencefP

7、ugs．Conclusion：Inthecaseoffemoralfracture，surgerycombinedwithLeigongtengOralSolutionWaseffectivetopromotefracturehealingandreducehealingtime．HoweverthemechanismunderlyingtheeffectsWasstillunknownandmoreworkneedtobedone．KeyWords：tripterygium，fracturehealing，mechanismN万方数据雷公藤口服液对

8、股骨骨折愈合影响的初步临床观察．】▲-．^一刖吾股骨骨折经过手术矫正固定后可以痊愈，但是由于骨质生长速度慢，