资源描述：
《帕金森病患者的脑结构与功能多模态磁共振成像分析》由会员上传分享，免费在线阅读，更多相关内容在行业资料-天天文库。
1、第三军医大学硕士学位论文StructuralandFunctionalMRIstudiesinParkinson’sdiseaseAbstractPARTI.MildcognitiveimpairmentinParkinson'sdisease:Avoxel-basedmorphometrystudyBackgroundsandobjective:Parkinson’sdisease(PD)isaneurodegenerativedisordercharacterizedbyaslowandprogressivedegenerationofdop
2、aminergicneuronsinsubstantianigra(SN)thatleadstolossofdopamine(DA)terminalsinthestriatum.Amongallthenon-motorsymptoms,cognitiveimpairmentbecomefocused.TheMildcognitiveimpairment(MCI)isoftenaccompaniedbyPD,evenearlyinthedisease,whichistheriskfactorofParkinson'sdiseasewithdemen
3、tia.ThepurposeofthisstudywastoinvestigatethechangesofgreymatterinParkinson'sdisease(PD)patientswithmildcognitiveimpairment(MCI)usingvoxel-basedmorphometry(VBM).Methods：Totally43PDpatientswereclassifiedusingcognitivetestingasPDwithnormalcognition(singlePD,n=21)andPDwithMCI(PD-
4、MCI,n=22).And20normalcontrols(NC)wereenrolled.T1WIwerederivedusinga3.0TMRscanner.ThedifferencesgreymattervolumeswereevaluatedusingVBM.Inordertoexaminethegraymatterdifferencebetweeneachtwogroups,two-samplet-testwasperformedinSPM8,resultsweredisplayedusingRESTsoftwarewithathresh
5、oldofP<0.05withmultiplecomparisoncorrectedbyFDRmethods.Results：Nosignificantdifferenceswerefoundbetweenthethreegroupsingender,age,height,weightandeducation.ComparedwithNC,PD-MCIexhibitedreducedgreymattervolumeinbilateralfrontalcortex,bilateralcerebellum,therightoccipitallobe,
6、aswellasinlefttemporallobe,posteriorcingulateandthehippocampus(P<0.05,FDRcorrected).PDpatientswithoutMCIshowedlimitedgreymatteratrophyinthelefttemporalandfrontal3第三军医大学硕士学位论文cortex(P<0.05,FDRcorrected).ComparedtoPDpatientswithoutMCI,areasofgreymatterintheleftmiddletemporalgyr
7、usandparahippocampalreducedinPD-MCIpatients(P<0.001,uncorrected).Conclusion:PDwithMCIisassociatedwithstructuralneocorticalchangesinthebrain,suggestingthattheremayexistagradientofneuropathologystructuresinPD.Keywords：Parkinsondisease;Mildcognitiveimpairment;Voxel-basedmorphome
8、tryPARTII.LocalizationofcerebralfunctionaldeficitsinPDpatientswithmil
