慢性丙型肝炎中西医治疗临床研究

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1、目录中文摘要·················．．．．．．．．．．．．．．．．．．．．．1英文摘要············-·······．．．．．．．．．．．．．．．．．．2引言⋯⋯⋯⋯⋯⋯⋯⋯．．．．．⋯⋯．．．．⋯．．4正文⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯．．51文献研究··⋯···⋯·····⋯⋯⋯．．．．．⋯⋯⋯⋯．．51．1中医对慢性丙型肝炎的认识·······．．．．．．．．．．．．．．．．52现代医学对丙型肝炎的认识·······．．．．．．．．．．．．．．．．．92．1现代医学对丙型肝炎病毒的

2、认识····．．．．．．．．．．．．．．．．．．92．2丙型肝炎病毒的致病机制及传播途径⋯⋯⋯⋯⋯⋯．．1o2．3慢性丙型肝炎的诊断···········-·．．．．．．．．．．．．．．．102．4慢丙肝的治疗·················．．．．．．．．．．．．．．113临床研究····················．．．．．．．．．．．．．．133．1研究内容·······⋯···⋯····．．．⋯．．⋯．⋯．133．2实验方案····················．．．．．．．．．．．．．．．．

3、．133．3给药方法·······-···········．．．．．．．．．．．．．．．．．．143．4合并用药···················．．．．．．．．．．．．．．．．．153．5观察项目⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯．．153．6疗效标准···················．．．．．．．．．．．．．．．．．153．7随访情况···················．-．．．．．．．．．．．．．．．163．8统计处理··················二．．．．．．．．．．．．．．．．．164结果·

4、-·····················．．．．．．．．．．．．．．．．165病例脱落情况················．．．．．．．．．．．．．．．．196不良反应··································2O7讨论······································208结论··························-··········23参考文献⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯·24综述········-·················

5、·········32致谢·············-·························38攻读学位期间发表的学术论文目录······⋯········39作者声明···一··-··························40个人简历·································41英文缩写HCVHCV：RNA主要缩略词表英文全名中文全名HepatitisCvirus丙型肝炎病毒HepatitisCRibonucleiacidPEG-IFNPeg—interfero

6、n心【Anti．HCVEVRETVRSVRTCMCHCMHCIL．2RDBHCCI也Vvirus丙型肝炎病毒核糖核酸聚乙二醇干扰素alanineaminotransferase丙氨酸基转移酶hepatitisantibodyearlyresponseCvirus丙型肝炎病毒抗体virological早期病毒学应答endoftreatmentvirologicalresponsesustainedvirologicresponsetraditionalChinesemedicinechronichepatiti

7、sCmajorhisticompatibilitycomplexinterleukin．2reversedotblothepatocellularcarcinomaribavirin治疗结束病毒学答持续病毒学应答中药慢性丙型肝炎主要组织相容复合体白细胞介素．2反向点杂交肝细胞癌利巴韦林中文摘要目的：观察中西医结合治疗慢性丙型肝炎的近期临床疗效。方法：对本院182例慢性丙型肝炎(CHC)病毒感染者及早期肝硬化患者作为研究对像。有抗病毒适应症者分为治疗组(聚乙二醇干扰素+利巴韦林+中药基本方)和对照组(聚乙二醇干

8、扰素+利巴韦林+中药安慰剂)，无抗病毒适应症者分为中药组(中药基本方)和中药安慰剂组(中药基本方原方药量的1／10)，据病毒性肝炎(HCV)基因型分类疗程24-48周，随访24周，观察治疗前后肝功能、丙型肝炎病毒核糖核酸(HCV．RNA)载量、不良反应、舌象及症状改善情况。结果：治疗组的丙氨酸基转移酶(触』)改善优于对照组，差异有统计学意义(尸<0．05)。两组患者有相似的不良反应，但恶心呕吐、乏力