乙型肝炎孪生子和非孪生子hbv pres1s2区准种特性及其与临床表型关系的初步研究

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1、第三军医大学硕士学位论文英文缩写一览表缩写英文全称中文全名Aadenosine腺苷aaarulnoacid氨基酸AIJalanineaminotransferase丙氨酸转氨酶AsCasymptomaticcarrier无症状携带者ASTaspartateaminotransferase天冬氨酸氨基转移酶bpbasepair碱基对CTLcytotoxicTlymphocyte细胞毒性T淋巴细胞CSGEconformation-sensitivegdelectrophoresis构象敏感凝胶电泳DNAdeoxyribonucleicacid脱氧核糖核酸dNTPdeoxynuc

2、leosidetriphosphate脱氧核苷三磷酸DZdizygotictwins双卵孪生子EBethidiumbromide溴化乙锭EDTAethylenedinitrilotetraaceticacid乙二胺四乙酸FQ—PCRfluorescencequantitativePCR荧光定量PCRHBsAghepatitisBsurfaceantigen乙型肝炎表面抗原HBsAbhepatitisBsurfaceantibody乙型肝炎表面抗体HBeAghepatitisBeantigen乙型肝炎e抗原HBeAbhepatitisBeantibody乙型肝炎e抗体HBcA

3、bhepatitisBcoleantigen乙型肝炎核心抗体HBVhepatitisBvirus乙型肝炎病毒HCVhepatitisCvirus丙型肝炎病毒HDAheteroduplexanalysis异源双链分析HⅣhumanimmunodeficiencyvirus人免疫缺陷病毒HLAhumanleukocyteantigen人白细胞抗原LAMlamivudine拉米夫定LBLuria—bertainmediumLB培养基LPCRlongerPCR长片段PCRMHCmajorhistocompatibilitycomplex主要组织相容性复合体MZmonozygotic

4、twins单卵孪生子ntnucleotide核菅酸第三军医大学硕士学位论文ORFopen-readingframe开放阅读框PAGEpolyacrylamidegelelectrophoresis聚丙烯酰胺凝胶电泳PCRpolymerasechainreaction聚合酶链反应preC／Cpre—coreandcoregene前C和C基因preS／Spre-surfaceandsurfacegene前s和S基因rpmrevolutionsperminute每分钟转速SDSsodiumdodecylsulfate十二烷基磺酸钠SSCPsinglestrandconformat

5、ionpolymorphism单链构象多态性Tthymidine胸苷TEMEDN’，N’，N’，N'-tetramethyldiamineN’，N’，N’，N’一四甲基乙二胺TNFturnoutnecrosisfactor肿瘤坏死因子Trishydroxymethylaminomethane三(羟甲基)胺基甲烷第三军医大学硕士学位论文TheprimarycomparativeanalysisbetweenthequasispeciesofpreSl／S2regionofHBVandtheirrelationshipswithclinicalmanifestationoftw

6、insandsiblingsAbtractHepatitisBseverelythreatenstothehealthofthepeople．TheoutcomeofhepatitisBvirus(HBV)infectionishighlyvariable，rangingfromasymptomaticdiseasesculminatinginthespontaneouseliminationofinfectiontopersistentinfectionthatcanleadtocirrhosis，liverfailureorhepatoceUularcarcinoma(

7、HCC)．Thefactorswhichdeterminetheoutcomeinanindividualpatientarepoorlyunderstoodbutmaybeclassifiedintothreecategories：viral，hostandenvironmentalfactors．ThebroaddefinitionofHBVvariationincludesgenotypewhichembodysthedifferenceofHBVamongthepeopleandviralmutationi