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1、MethodsandcompostionsforenhancingtransdermaldrugdeliveryUS20090291133A1摘要Methodsandcompositionsforenhancingtransdermaldeliveryofabioactiveagent.Themethodcontainsthestepofapplyingtoaskintissueaneffectiveamountofacompositioncomprising:(a)adrugvehicle;(b)abioactiveagentencapsulatedwithinthedrugv
2、ehicle;(c)apluralityofproteolyticenzymemoleculesconjugatedontothesurfaceofthedrugvehicle;and(d)apharmaceuticallyacceptablecarrier,foraperiodoftimeeffectivetodeliverthebioactiveagentacrosstheskintissueatadesireddosage・图片(3)权利要求(20)1.Amethodforenhancingdeliveryofabioactiveagentacrossaskintissue
3、comprisingthestepof:applyinganeffectiveamountofacompositioncomprising:a)adrugvehicle;b)abioactiveagentencapsulatedwithinthedrugvehicle;c)apluralityofproteolyticenzymemoleculesconjugatedontothesurfaceofthedrugvehicle;andd)apharmaceuticallyacceptablecarrier,foraperiodoftimeeffectivetodeliverthe
4、bioactiveagentacrosstheskintissueatadesireddosage.1.ThemethodofclaimI,whereinthedrugvehicleisaliposome・2.Themethodofclaim2,whereinthecompositionfurthercomprisesananoparticleenclosedintheliposome,whereinthebioactiveagentisencapsulatedwithinthenanopariclewithintheliposome.3.Themethodofclaim3,wh
5、ereinthenanoparticleisformedfrompoly(lactic-co-glycolicacid)(PLGA)orhydro-gel.4.Themethodofclaim1,whereintheproteolyticenzymeispapain.5.Themethodofclaim5,whereintheconcentrationofpapainislessthan93,orlessthan50,40or30pg/ml.6.Themethodofclaim1,whereintheproteolyticenzymeisaselectedfromthegroup
6、consistingofpapain,pancreatin,ficin,bromelain,elastase,pepsin,hyaluronidase,streptokinase,streptodomase,trypsin,chymotrypsin,a-chymotrypsin,a-amylase,deoxyribonucLIease,collagenase,sutilainandanycombinationthereof.7.Themethodofclaim1,whereinthebioactiveagentcomprisestwoormorethantwotypesofbio
7、activeagents.8.Themethodofclaim8,whereinthetwoormorethantwotypesofbioactiveagentscomprisesatleastonetypeofhydrophilicbioactiveagent.9.ThemethodofclaimI,whereinthebioactiveagentisahormone.10.Acompositionfortransdermaladministrationofabioactive
