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时间:2018-11-16
《s100a2在喉鳞状细胞癌中的表达及其意义论文》由会员上传分享,免费在线阅读,更多相关内容在工程资料-天天文库。
1、S100A2在喉鳞状细胞癌中的表达及其意义论文【摘要】目的研究S100A2蛋白在喉鳞癌(laryngealsquamouscellcarcinoma,lscc)中蛋白表达的情况,探讨其在喉鳞癌发生、发展、浸润转移中的作用。方法收集40例泸州医学院附属医院耳鼻咽喉-头颈外科2005年1月至2007年5月手术切除经病理诊断证实为喉鳞癌(LSCC)患者病理组织石蜡标本作为实验组,另取40例同期手术切除经病理证实无肿瘤浸润的癌旁喉粘膜组织标本作为对照组。所有石蜡标本按4μm连续切片2张,其中1张HE染色,另外1张用免疫组织化学染色SP法检测S10
2、0A2蛋白的表达。以试剂盒内阳性切片作为阳性组,用磷酸盐缓冲液(PhosphateBufferSolution,PBS)代替一抗做阴性对照。具体实验步骤参照试剂盒说明,显微镜下观察喉鳞癌组织及无肿瘤浸润的癌旁粘膜组织各组细胞中S100A2的分布情况并计数其阳性表达率。结果喉鳞癌及正常喉粘膜组织中S100A2蛋白表达位于胞核和胞浆,呈黄色至棕黄色着色。40例无肿瘤浸润的癌旁喉粘膜组织中S100A2蛋白全部为阳性表达,表达率为100%(40/40),40例喉癌组织中S100A2蛋白表达率为78%(31/40).freelouscellcanc
3、er(LSCC)andtodiscussitspotentialroleintheoccurrence,developmentandmetastasisoflaryngealsquamouscellcancer.MethodsThepathologicaltissuesfrom40casesedbyoperationandpathologicalstudyucosaltissuesamplesadjacenttocancerlocationfrom40casesedbyoperationandpathologicalstudythickn
4、essalltheparaffintissues,onedyedmuno-histochemicmethod;SPmethodentalstepsjustfolloicroscopeobservationadetothedistributionofS100A2proteinexpressioninthetissuecellsofLSCCandinthemucosaltissuecellsadjacenttocancerlocationallaryngealmucosaltissueainlylocatedinthenucleusandcy
5、toplasminyelloucosaltissuesfromthe40casesucosaltissuecellsadjacenttocancerlocation(P<0.05);thepositiveexpressionrateofS100A2proteininLSCCofdifferentdifferentiationsrangedasfollooderatedifferentiationand25%inpoordifferentiation;thereoderatedifferentiation(P=0.876)buttheirr
6、atesthedifferentiationofLSCC;thepositiverateofS100A2proteininthetissuesofLSCCphnodemetastasisphnodemetastasis(P<0.05);thepositiveexpressionrateofS100A2proteininT1~T2classificationphnodemetastasisbutisnotrelatedtotheclassificationandtheageofpatients,itcanbeinferredthatS100
7、A2proteinplaysanimportantroleintheincidence,developmentandinfiltrativemetastasisofLSCC;2.S100A2proteinisakindofcancerinhabitinggene,thedetectionofS100A2proteinexpressionmaybeoneofthereferenceindexforthejudgmentofbiologicalbehaviorofthecellsofLSCC.KEY分期进行分组。年龄以60岁为界,分为两组;按
8、组织病理学分级分为高分化鳞癌22例,中分化鳞癌10例,低分化鳞癌8例;有淋巴结转移22例,无颈淋巴结转移18例;按1997年国际抗癌协会(UICC)制定的TNM分期,T1~T2期有14例,T3
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