血脂水平异常与结直肠癌肝转移的相关性研究

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1、血脂水平异常与结直肠癌肝转移的相关性研究［摘要］H的探讨血脂水平异常与结直肠癌肝转移的关系。方法回顾性分析2008年6月〜2016年3月宝鸡市中医医院普外科及肛肠科收治的336例结直肠癌患者的临床资料，分析比较结直肠癌肝转移组（52例）及非肝转移组（284例）患者的一般临床资料及初次血脂水平，分析结直肠癌肝转移与血脂水平及异常血脂类型之间的关系。结果结直肠癌肝转移组的肿瘤浸润深度、是否存区域淋巴结转移及肿瘤分化程度与无肝转移组差异有统计学意义（P〈0.05），两组初次CEA水平差异无统计学意义（P〉0.05）;肝转移组的血脂水平高于非肝转移组，差异有统计学意义（P〈0.

2、05）；多元Logistic回归分析显示:高三酰甘油血症及高？固醇血症均为结直肠癌发生肝转移的独立危险因素（P〈0.05），且与高密度脂蛋白及低密度脂蛋白的异常无关（P〉0.05）。结论高胆固醇及三酰高甘油水平可能促进结直肠癌的肝转移本文采集自网络，本站发布的论文均是优质论文，供学习和研究使用，文中立场与本网站无关，版权和著作权归原作者所有，如有不愿意被转载的情况，请通知我们删除匕转载的信息，如果需要分享，请保留本段说明。［关键词］血脂异常；结直肠癌；肝转移；高廿油三脂血症；高胆固醇血症［中图分类号］R735.3［文献标识码］A［文章编号］1673-7210(2017)

3、06(b)-0092-04Studyonrelationshipbetweenabnormalityofblood1ipidlevelandlivermetastasisofcolorectalZHANGRuiDepartmentofGeneralSurgery,ChineseMedicineHospitalofBaojiCity,ShaanxiProvince,Baoji721001，China［Abstract］ObjectiveToinvestigatetherelationshipbetweencolorectalcancerpatientswithliverm

4、etastasesandabnormalbloodlipidlevels.MethodsFromJune2008toMarch2016，inDepartmentofGeneralSurgeryandDepartmentofAnorectalSurgery,ChineseMedicineHospitalofBaojiCity,theclinicaldataof336patientswithcolorectalcancerwereanalyzedretrospectively.Theyweredividedintocoloractalcancerwithlivermetas

5、tasesgroup(52cases)andcolorectalcancerwithoutlivermetastasesgroup(284cases).Theclinicaldataandinitialbloodlipidlevelsofcolorectalcancerwereanalyzedandcompared,therelationshipofcolorectalcancerwithlivermetastasespatientsandlipidlevels,abnormalbloodlipidswasanalyzedstatistically.ResultsThe

6、rewerestatisticallysignificantdifferencesinthedepthoftumorinvasion，regionallymphnodemetastasisandtumordifferentiationdegreebetweenthetwogroups(P<0.05).TherewasnostatisticallysignificantdifferencesintheprimaryCEAlevelbetweenthetwogroups(P>0.05).Theblood1ipidlevelsofcolorectalcancerwithliv

7、ermetastasesgroupwerehigherthanthecolorectalcancerwithoutlivermetastasesgroup，thedifferenceswerestatisticallysignificant(P<0.05).MultivariateLogisticregressionanalysisshowedthathypertriglyceridemiaandhypercholesterolemiawerebothindependentriskfactorswithlivermetastasisinc