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1、HERPESSIMPLEXVIRUSCharacteristicsofHSVDNAdoublestrandedvirus,linear125-250Kblong,relativelybigEnvelopedVirionsize200nm,relativelybig9HSVs,Ex.Varicella,EBV,CMVDiseases:Chickenbox,Mononucleosis,Hepatitis,EncephalitisRecurrenteye,mouthandgenitallesionsChickenpox,VaricellaZosterHerpesVi
2、rusandCommonDiseasesEverybodyknowschickenpoxandlikelyyouexperiencedthediseaseasachild,canbedangerouswhenexposedtoitinadulthoodAnothercommonailmentislipandmouth“coldsores”GenitalHerpeslesionscausedbyHSV,sexuallytransmittedHSV-1coldsores(mildbutannoyingdiseases)HSV-2genitalherpesVaric
3、ellazoster:chickenpoxHowevertheHerpesfamilyishuge,over100membersHSV-1ColdsoreHSV-2GenitalHerpesHSVEstablishesLatentInfectionsOnceinfectionhastakenplaceHSVcanremaindormantformonths,years,lifetimeCelltypesthatHSVcaninfectandremaindormantNeurons,B-cellsandT-cellsExamples:Shingleswhichc
4、anappearyearsafterfirstchickepoxinfection(causedbyvaricellazoster,causesbothchickenpoxandshingles)GenitalHerpesoutbreaksHerpes(1-2)SimplexVirusGenomeHSVCapsidEnclosedinanenvelopeCapsidhasicosahedralstructureCapsidisbilayeredConstructedfrom6proteinsVP5isthemainoneEnvelopecontainsatle
5、ast10differentglycoproteinsgB-gMEnvelopealsocontainsnon-glycosylatedproteinsHSVEntryIntoHostOccursViaHeparanSulfateProteoglycansgBandgCbindtohostglycoproteinswithheparansulfatemoieties(repeatingdissacharide:glucoronicandn-acetylglucosamine)FollowinggBandgCisgDwhichbindstonectin1DORH
6、VEM(herpesvirusentrymediator)FusionoccursbetweenviralenvelopeandhostmembraneNucleocapsidisreleasedintocytosolORinacidifiedendosomesTransporttonuclearenvelopeoccursviaTandcapsidinteractionDNAisreleasedintonucleusCapsiddisintegrateshttp://www.dipartimentobiologia.it/doctoraltraining/
7、campadelli.htmGenomeExpressioninNucleusViralDNAiscircularizedonceinsidenucleusViralDNAislocalizedinregionsreferredtoasND10(nucleardomain10)ViralgenestranscribedbycellularRNAPolyIIGeneexpressiondividedinto4groupsGroupoccurswithinhoursofviralinfection(thesegenesalsoreferredtoas“immed
8、iateearlygenes”)ge