herpes simplex virus herpes zoster 疱疹病毒科单纯疱疹病毒带状疱疹课件

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1、11InfluenzaA,B,Cviruses●Klasifikasi,Struktur,Genom,KulturdanSifatVirus-FamiliOrthomyxoviridaeInfluenzaAvirustdd:subtipe~15HAdan9NA(~outbreaksinhumans:H1-3danN1-2)-Virionberbentukspheris,tdd:a.Segmented,minusstrandRNAb.Helicallycoilednucleocapsidc.Enveloped(hemagglu

2、tinin&neuraminidaseglycoproteinspikes)2Genom:13000-15000nt,tdd7-8segmen(reassortment!);menyandi10-11macamprotein.InfluenzaCvirus:genNAӨDapatdikulturpadaa.l.monkeykidneycellsHost:InfluenzaAvirus:wildavian,humans,swine,horsesInfluenzaB&Cvirus:humans:swine,dogs,cats,h

3、orseInaktivasidgn:radiasiionisasi,pH<5/>9,>50C,deterjen,drying33-Seasonal:winter/spring(temperate)&rainy(tropic)(InfluenzaCvirus:nonseasonal)-InfluenzaAvirus:>avian;~epidemikinfluenza(peranswine):nonhuman&human(reassortment!)InfluenzaB&Cvirus:~milderdisease;winter

4、outbreaks●Epidemiologi-Worldwideoutbreaktiaptahunpandemik:InfluenzaAvirusH1N1(swine)1918,H2N2(Asian)1957,H3N2(Hongkong)1968,H5N1(chicken/bird)19971947:WHOsurveillanceprogram4-Lowmortality(~lowerrespiratory/cardiovasculardisease)-Transmisi:byairbornedroplets(orangke

5、orang,zoonotik)-Seringreinfeksi-~Infeksinosokomial(InfluenzaAvirus>>)●ManifestasiKlinis-Gejala/sindromainfluenza(allagegroups)-Komplikasi:sering(otitismedia/sinusitis,bronchitis,croup,pneumonia,CNS,myocarditis,gagalginjalakut)55●DiagnosisLab-Isolasivirusdarisputum,

6、usaphidung/tenggorok,nasalaspirate/washing(kultursel)&deteksiCPE-Deteksiasamnukleat(RT-PCR)-Ujiserologis:deteksiag&ab(IF,RIA,EIA)●Prevensi(vaksin,isolasipenderita:diRS,antiviral)●Terapi(simtomatikdanantiviral)6Parainfluenzavirus●Klasifikasi,Struktur,GenomdanKulturV

7、irus-GenusParamyxovirus,FamiliParamyxoviridaePIV:tipe1,tipe2,tipe3,tipe4-Virionberbentukpleomorfik(spheris/filamentous)tdd:a.SinglestrandedofnegativesenseRNAb.Helicalnucleocapsidc.Envelope(spike-likeglycoproteins&lipidfromhostcell)-Genomtdd15500ntygmengkode6VP(H=h

8、emaglutinin,N=Neuraminidase)&1NSP-Dapatdikulturpadamonkeykidneycells7●Epidemiologi-Worldwide(earlychildhood)mortalitas:~pneumonia(anak<5tahun)di