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1、肠道菌群与代谢疾病目录肠道菌群与健康和疾病概述肠-脑轴肠-肝轴肠道菌群与代谢性疾病：肥胖、糖尿病肠道菌群与肠病肠道菌群与免疫肠道菌群与其它疾病革命带来的挑战和机遇悄悄发生的革命INNASEKIROV,etal.,GutMicrobiotainHealthandDisease.PhysiolRev90:859–904,2010;一篇值得关注的综述Naturereviews.Microbiology最新的影响因子为22.490(2013)人菌共生KristinaHarris,etal.,IstheGutMicrobiotaaNewFactorContributingtoObesityandIts
2、MetabolicDisorders?JournalofObesity,Volume2012,p1-14.人肠道菌群种类和数量EAMONNM.M.QUIGLEYandRODRIGOQUERA,SmallIntestinalBacterialOvergrowth:RolesofAntibiotics,Prebiotics,andProbiotics.GASTROENTEROLOGY2006;130:S78–S90好细菌和坏细菌菌群是健康的核心NathalieM.Delzenne,etal.,Targetinggutmicrobiotainobesity:effectsofprebioticsa
3、ndprobiotics.Nat.Rev.Endocrinol.7,639–646(2011).肠道菌群对人生理的影响肠道菌群-代谢产物-功能JeremyK.Nicholsonetal.,Host-GutMicrobiotaMetabolic.Science336,1262-1267,2012.影响肠道菌群的因素NathalieM.Delzenne&PatriceD.Cani,InteractionBetweenObesityandtheGutMicrobiota:RelevanceinNutrition.Annu.Rev.Nutr.2011.31:15–31.影响肠道菌群的因素肠-脑轴/脑
4、-肠轴GermFree(GF)MiceDisplayIncreasedMotorActivityandReducedAnxiety-LikeBehavior.resultssuggestthatthemicrobialcolonizationprocessinitiatessignalingmechanismsthataffectneuronalcircuitsinvolvedinmotorcontrolandanxietybehavior.肠-脑轴的概念AugustoJ.Montiel-Castro,etal.,Themicrobiota–gut–rainaxis:neurobehavio
5、ralcorrelates,healthandsociality.FrontinIntegNeuro.Oct2013
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8、1-16.脑-肠轴/肠-脑轴：迷走神经SueGrenham,etal.,Brain–gut–microbecommunicationinhealthanddisease.FrontiersinPhysio.GastrointSciDec2011Vol2p1-15.肠脑轴/脑肠轴Q.AZIZ,etal.,Gutmicrobiotaandgastrointestinalhealth:currentconceptsandfuturedirections
9、.NeurogastroenterolMotil(2013)25,4–15.菌群影响神经功能EamonnM.M.Quigley.Dopatientswithfunctionalgastrointestinaldisordershaveanalteredgutflora?TherAdvGastroenterol(2009)2(Suppl1)S23–S30.菌群紊乱致焦虑和抑郁JaneA.FosterandKaren-AnneMcVeyNeufeld,Gut–brainaxis:howthemicrobiomeinfluencesanxietyanddepression.TrendsinNeur
10、osciences,May2013,Vol.36,No.5,P305-312精神活动影响肠道菌群JasonA.Hawrelak&StephenP.Myers,TheCausesofIntestinalDysbiosis:AReview.AlternMedRev2004;9(2):180-197.exposuretopsychologicalstressresultsinasignificantreductio
