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1、Theconstructionsandfunctionsofskin皮肤结构和功能Prof.DanqiDeng(邓丹琪教授、博导)Dept.ofDermatology,theSecondAffiliatedHospitalofKunmingMedicalUniversityhttp://sy.ynderma.com.cnHealthybodydependonhealthskin.Theskinisaaesthetic(审美)organ.Theskinisavitalorganlikeheartis.OutlineEpidermis表皮Dermis真皮Subcutaneoustissue皮下组织
2、Cutaneousappendage皮肤附属器Thefunctionsofskin皮肤的功能Theskinanatomy(皮肤的解剖)Itisthelargestorganofthebody,makingup16%ofbodyweight,withasurfaceof1.5m2Thedepthofskinis0.5~4mm.Theepidermis(表皮)is0.04-1.6mm,theaveragedepthofepidermisis0.1mm.Thedermis(真皮)is1-3mm.TheskinanatomyIt’scontinuouswiththedigestivesystem(li
3、ps).腔口部位形成皮肤黏膜的移行区Theskingrooves(皮沟)andskinridges(皮嵴)Therearethreestructurallayerstotheskin:theepidermis(表皮),thedermis(真皮)andsubcutis(皮下组织)Thedermiscontainsnerveendings,sweatglands(汗腺)andoilglands,hairfollicles(毛囊),andbloodvessels(血管).ThecolorofskinTypeITypeIITypeIIITypeIVTypeVTypeVIThetypeofskinThe
4、epidermis(表皮)Theepidermisisanepithelium(上皮)comprisedofkeratinocytes(角质形成细胞)anddendriticcells(langerhanscells朗格汉斯细胞,merkelcells麦克尔细胞,melanocytes黑素细胞).Themaincellsoftheepidermisarethekeratinocytes(角质形成细胞80%),whichsynthesisetheproteinkeratin(角蛋白).stratumbasale,基底层stratumcorneum角质层stratumspinosum棘层strat
5、umgranulosum颗粒层stratumlucidum透明层Theepidermis(表皮)Stratumbasale(基底层):isamajorregionofmitotic(分裂)activity.Thebasallayeriscomposedofcolumnar(柱状)cellswhichareanchoredtoabasementmembrane(基地膜)Epidermaltransittime(表皮通过时间或更替时间):Newkeratinocytesslowlymigrateuptowardthesurfaceoftheepidermis.Theprocessneeds28da
6、ys.Fromstratumbasaletostratumgranulosumis14days,thentostratumcorneumandgraduallyshedis14days.Totalis28days.Stratumspinosum(棘细胞层)iscomposedof4to8layersofprickle(多角形的)keratinocytes.Keratinocytesareattachedtoeachotherbyintercellularbridge(细胞间桥),whicharedesmosomes(桥粒)Stratumgranulosum(颗粒层)Locatedtheuppe
7、rofstratumspinosum.Stratumgranulosumiscomposedof1to3layersofratherflattened(扁平)cells.Therearesomelargeandbasophil(嗜碱性)granule,calledkeratohylinegranules(透明角质颗粒)incytoplasm(细胞浆).ratherflattenedcellscon
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