如何知道输卵管堵塞石家庄女性输卵课件

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1、LeishmaniasisLeishmaniadonovani(complex)(VL)Leishmaniatropica(CL)Leishmaniamajor(CL)Leishmaniaaethiopica(CL)Leishmaniamexicana(Complex)(CL)Leishmaniabrazilliensis(complex)(MCL)LeishmaniaperurianaTheParasitePhylumOrderFamilyGenusSarcomastigophoraKinetoplastidaTrypan

2、osomatidaeLeishmaniaMorphologyPromasitogteInsectMotileMidgutAmastigoteMammalianstageNon-motileIntracellularDigeneticLifeCycleMorphologyPromastigoteAmastigoteFlagellaKinetoplastGolgiNucleusCytoskeletonPromastigoteAmastigotes(*)ofLeishmaniadonovaniinthecellsofaspleen

3、. Theindividualamastigotesmeasureapproximately1µmindiameter.AmastigoteAmastigotesofLeishmaniainamacrophagefromalymphnodeofadog.Leishmania(Leishman-DonovanorLDbodies).Lyinginmacrophagecellsfromliver.Giemsa.×12000.Enlargedby9.6.AmacrophagefilledwithLeishmaniaamastigo

4、tes.LifecycleTheorganismistransmittedbythebiteofseveralspeciesofblood-feedingsandflies(Phlebotomus)whichcarriesthepromastigoteintheanteriorgutandpharynx.Itgainsaccesstomononuclearphagocyteswhereittransformintoamastogotesanddividesuntiltheinfectedcellruptures.Therel

5、easedorganismsinfectothercells.Thesandflyacquirestheorganismsduringthebloodmeal,theamastigotestransformintoflagellatepromastigotesandmultiplyinthegutuntiltheanteriorgutandpharynxarepacked.Dogsandrodentsarecommonreservoirs.MammalianHostsRodentsGerbilsHyraxesBatsPorc

6、upinesOpossumsSlothsPrimatesDogsFoxesAnteaters.....VectorsPhlebotomineSandflies6generaworldwidedistributionPhlebotomus&Lutzomia500speciesFemalesHaematophagusMalessapfeedersClinicalDiseaseVisceralFatal(90%untreated)LiverSpleenBonemarrowCutaneousGenerallySelf-healing

7、SkinMucousmembranesSPECTRUMOFDISEASEInitialInfectionSimilarinallspeciesInoculationofpromastigotesInflammation&chemotaxisReceptormediatedphagocytosisPromastigoteAmasitgoteTransformationParasiteSpreadMacrophagelysis¶sitereleaseLymphaticspreadBloodspreadTargetorga

8、nsSkin/lymphnodes/spleen/liver/bonemarrowVisceralLeishmaniasis190319201931WilliamLeishmanPentavalentantimonyExperimentaltransmissionLeishmaniadon