丹参注射液对梗阻性肾病大鼠肾功能及tgfβ1表达的影响

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1、気歌廣符匣斤坑怦來楓押寄報楓孔嬬式TGF・β1燕器議唹・恬宀・告夾碕旗遑仞桔扮酷昆争柾床墳痩敢‐姜勣／・朕議・鉱賀気歌廣符匣斤坑怦來楓押寄報楓怏岶廬晒伏海咀徨β1・TGF・β1・燕器、楓孔嬬式楓押尖怏岶僥議唹・。・圭隈・寡喘磯潤奢隈秀羨挺揃坑怦來楓押寄報庁侏・鉱賀気歌廣符匣嵶粗來公勞斤挺揃坑怦來楓押寄報楓怏岶TGF・β1燕器・RT・PCR隈・、僮賠次・・珠來逗龍磨隈・、挺殆紀・挺殆淡隈・式楓押尖怏岶僥・械号He半弼・議唹・。・潤惚・1、寄報挺揃坑怦3d・庁侏斤孚怏僮賠次・、挺殆紀譲幅互・凪嶄挺殆紀幅互苧・・嗤・广來餓呟・徽僮次・幅

2、互音苧・・気歌嵶粗怏潤惚窃貌。宝朔3d庁侏斤孚怏才気歌嵶粗怏僮賠次・、挺殆紀曳熟・譲P>0.05。寄報挺揃坑怦14d僮賠次・、挺殆紀隔偬幅互。気歌嵶粗怏僮賠次・、挺殆紀譲週詰・凪嶄挺殆紀週詰苧・・徽挽互噐邪返宝怏。寄報挺揃坑怦56d・庁侏斤孚怏僮賠挺殆紀壓互了邦峠・遇僮次・延晒音苧・・気歌嵶粗怏潤惚窃貌。2、嚥邪返宝怏曳熟・庁侏怏楓TGF・β1mRNA格互燕器迫米・気歌嵶粗怏光扮泣斤楓怏岶TGF・β1mRNA燕器隆需苧・唹・・徽迫米・幣気歌嵶粗公勞辛嬬嗤煤裏雙崙TGF・β1mRNA燕器。3、押尖潤惚・庁侏怏楓弌白式楓弌砿格耕

3、抹來個延・楓弌砿鴻刑撒棒・気歌嵶粗怏楓弌白式楓弌砿格耕抹來個延・楓弌白倖艶撒棒。・潤胎・挺揃坑怦來楓押寄報海豚廣符気歌廣符匣嗤廁噐受富楓弌白撒棒、個鋲楓壜孔嬬。9‐購囚簡／坑怦來楓押・気歌廣符匣・廬晒伏海咀徨β1・寄報　　Abstract・・Objective・ToobservetheeffectofSalviaInjectiononobstructivenephropathyrats¨kidneyfunction,TGF・β1expression,pathologyandhistology,primarilydiscussits

4、protectivemechanism.・Method・Takehalf・ligationtosetratsmodelofurinaryobstruction,observetheeffectofSalviaInjectionontheirTGF・β1expression(RT・PCRmethod),serumcreatinine(picricacidmethod),BUN(ureasemethod),pathologyandhistology(routineHeDye).・Result・1.After3d,inmodelcont

5、rolgroup,theserumcreatinineandBUNareincreased,thelatterismoreapparent,withmarkeddifference;thatofSalviaInjectiontreatmentissimilar,allP>0.05.After14d,theyarecontinuallyincreased;butthatinSalviatreatmentgroupisdecreased,amongwhichBUNismoreapparent,butstillhigherthan

6、falseoperationgroup.After56d,theserumBUNisinhighlevelinmodelcontrolgroup,whilecreatininechangeslittle;Salviatreatmentgrouphassimilarresult.2.Comparedtofalseoperationgroup,theTGF・β1mRNAexpressioninmodelgroupisinhighlevel;there¨snomarkedeffectofSalviatreatmentgrouponTGF

7、・β1mRNAineverytime9point,butthetrendshowsSalviamayslightlyinhibititsexpression.3.Forthepathologicalresult:inmodelgroup,theglomerularandtubularareinshrinkagechange,thetubularisinbroadputrescence;soisinSalviatreatmentgroup,excepttheglomerularisinindividuallynecrosis.・Co

8、nclusion・LongapplyingSalviaInjectionishelpfultoreduceglomerularnecrosisandimprovekidneyfunctionforurinaryobstructivenephropa