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1、辽宁石油化工大学毕业设计(论文)用纸325吨/年硫酸双氢链霉素生产装置工艺设计摘要本课题为325吨/年硫酸双氢链霉素生产装置的工艺设计。在发酵过程中,每天需完成至少51.055m3(53607.75kg)发酵全液的生产。经计算,生产中选用8个75m3的发酵罐,发酵周期为8d,一、二、三级种子罐各4个,发酵周期为4d。菌种经一、二、三级种子罐逐级扩大培养后放罐入发酵罐中,在发酵罐中经8d发酵,产成51.055m3的发酵全液,后放入预处理罐内进行硫酸双氢链霉素的合成提取。发酵液进入预处理罐后,用草酸酸化至pH
2、3.0左右,通过板框过滤,除去大量杂质,再用NaOH中和至pH在6.7~7.2范围内。离开预处理罐的发酵液进入稀释罐进行稀释,后进入交换罐。在交换罐中采用1103Na型树脂对稀释液进行吸附,再经7%H2SO4溶液进行解吸,解吸完毕,采用活性炭粉对解吸液脱色。解吸后的解吸液在补还原罐中用NaBH4将硫酸链霉素还原为硫酸双氢链霉素,还原后的硫酸双氢链霉素经稀释、吸附、解吸精制、精脱、薄膜蒸发、成脱和离心喷雾干燥等步骤形成成品。关键词:硫酸双氢链霉素;生产装置;工艺流程;设计辽宁石油化工大学毕业设计(论文)用纸
3、Atechnologicaldesignof325t/adihydrostreptomycinsulphateproductionfacilityChengWei(Class0901,Departmentofbiologicalengineering,SchoolofEnvironmentalandbiologicalengineering,LiaoningShihuaUniversity,LiaoningFushun,113001,China)AbstractThistopicisthetechnolo
4、gicaldesignof325t/adihydrostreptomycinsulphateproductionfacility.Inthefermentationprocess,ithavetocompleteatleast51.055m3(53607.75kg)fermentationliquidproductioneveryday.Aftercalculation,theresultsisthattheproductiondesignselecteeight75m3fermenter,theferm
5、entationperiodwas8d,the1st,2nd,3rdseedtankisfour,respectively.After8dfermentation,51.055m3fermentationbrothisobtained.Thenthefermentationbrothisputintothepretreatmenttankforthesynthesisofdihydrostreptomycinsulfateextraction.Afterthefermentationbrothintoth
6、epretreatmenttanks,itisacidifiedtonearlypH3.0withoxalicacid.Thenitcanremovelargeamountsofimpuritiesthroughtheplateandframefilter,anditisneutralizedtoapHrangeof6.7to7.2withNaOH.Afterfermentationbrothleavingthetankintothedilutiontankfordilution,thefermentat
7、ionbrothflowsintotheexchangetank.Inexchangetank,ituses1103Natyperesinforadsorptionondilution.Thenthedilutionisdesorbedcompletelyby7%H2SO4solution.Afterdesorption,desorptionsolutionisdecoloredusingactivatedcarbonpowder.Afterdesorption,thestreptomycinsulfat
8、eindesorptionsolutionwillbereducedtodihydrostreptomycinsulfateusingNaBH4inthereductionpot.Afterreduced,dihydrostreptomycinsulfateformsfinishedgoodsthroughdilution,辽宁石油化工大学毕业设计(论文)用纸adsorption,desorptionrefined,losso
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